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Engineering Homogeneous Photoactive Antibody Fragments
Genetically encoded site-specifically incorporated noncanonical amino acids (ncAAs) have been used to modulate properties of several proteins. Here,...
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Homogeneous multi-payload antibody–drug conjugates
Many systemic cancer chemotherapies comprise a combination of drugs, yet all clinically used antibody–drug conjugates (ADCs) contain a single-drug...
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Design and Construction of Antibody Fusion Proteins Incorporating Variable New Antigen Receptor (VNAR) Domains
Antibody therapeutics have become a cornerstone of the pharmaceutical market due to their precise molecular targeting, favorable pharmacokinetic...
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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins
Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases....
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Understanding the Specific Implications of Amino Acids in the Antibody Development
As the demand for immunotherapy to treat and manage cancers, infectious diseases and other disorders grows, a comprehensive understanding of amino...
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Druggability properties of a L309K mutation in the antibody CH2 domain
In the early stages of antibody drug development, it is imperative to conduct a comprehensive assessment and enhancement of the druggability...
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Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody
Development and characterization of guinea pig anti-insulin polyclonal antibody against a target-specific insulin antigen. In India, an insulin...
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Ligand-Directed GPCR Antibody Discovery
Develo** affinity reagents recognizing and modulating G-protein coupled receptors (GPCR) function by traditional animal immunization or in vitro...
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Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4
Unlocking the potential of protein arginine deiminase 4 (PAD4) as a drug target for rheumatoid arthritis requires a deeper understanding of its...
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Probing Antibody Structures by Hydrogen/Deuterium Exchange Mass Spectrometry
Hydrogen/deuterium exchange (HDX) followed by mass spectrometry detection (MS) provides a fast, reliable, and detailed solution for the assessment of...
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Application of Computational Techniques in Antibody Fc-Fused Molecule Design for Therapeutics
Since the advent of hybridoma technology in the year 1975, it took a decade to witness the first approved monoclonal antibody Orthoclone OKT39...
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Antibody Purification Using Affinity Chromatography
Antibodies are an integral part of many biological assays and biotherapeutics. However, the sources from which antibodies are derived frequently...
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Application of the CRISPR/Cas9 Gene Editing Method for Modulating Antibody Fucosylation in CHO Cells
Genetic engineering plays an essential role in the development of cell lines for biopharmaceutical manufacturing. Advanced gene editing tools can...
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Enhancing antibody affinity through experimental sampling of non-deleterious CDR mutations predicted by machine learning
The application of machine learning (ML) models to optimize antibody affinity to an antigen is gaining prominence. Unfortunately, the small and...
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Combining nanotechnology with monoclonal antibody drugs for rheumatoid arthritis treatments
Rheumatoid arthritis (RA) is a systemic immune disease characterized by synovial inflammation. Patients with RA commonly experience significant...
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Method for Measurement of Antibody-Dependent Cellular Phagocytosis
Antibody-based therapeutics are powerful tools to treat disease. While their mechanism of action (MOA) always involves binding to a specific target...
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Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry
Microglia are brain-resident phagocytic cells, considered to be the innate immune cells of the central nervous system. Microglia respond to both...
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Application of a Novel Aptamer Beacon for Rapid Detection of IgG1 Antibody Drugs
Antibody drugs have been widely used to treat many diseases and are the fastest-growing drug class. IgG1 is the most common type of antibody because...
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Study of antibody repertoire to oligosaccharide fragments of polyglucosamines and galactosaminoglycans in sera from healthy human donors
Naturally circulating antibodies could dramatically change the activity of immunogens. In some cases, cross-interference between antibodies led to...
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The Therapeutic Antibody Profiler for Computational Developability Assessment
The need to consider an antibody’s “developability” (immunogenicity, solubility, specificity, stability, manufacturability, and storability) is now...