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Biosynthesis of β-Amino Acid-Containing Macrolactam Polyketides
β-Amino acid-containing macrolactam antibiotics are an important class of macrocyclic polyketides in Actinobacteria. These macrolactam antibiotics...
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Discovery of novel amino acid production traits by evolution of synthetic co-cultures
BackgroundAmino acid production features of Corynebacterium glutamicum were extensively studied in the last two decades. Many metabolic pathways,...
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Amino Acids
Since discovery of Corynebacterium glutamicum in 1956, amino acid production by microbial fermentation is one of most successful biotechnology models...
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Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A
β-Amino acid-containing macrolactams represent a structurally diverse group of bioactive natural products derived from polyketides; however we are...
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A 4-hydroxybenzoate 3-hydroxylase mutant enables 4-amino-3-hydroxybenzoic acid production from glucose in Corynebacterium glutamicum
BackgroundMicrobial production of aromatic chemicals is an attractive method for obtaining high-performance materials from biomass resources. A...
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Enhanced production of γ-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation
BackgroundBio-based aromatic compounds are of great interest to the industry, as commercial production of aromatic compounds depends exclusively on...
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Unnatural Amino Acid Engineering for Intracellular Delivery of Protein Therapeutics
Protein drugs are a critically important therapeutic modality due to the sophisticated binding recognition, catalytic properties, and disease...
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Coupling fermentation of glutamic acid and γ-polyglutamic acid and preparation of poly(amino acid) superabsorbent polymers
γ-polyglutamic acid (γ-PGA) is a biomarker that can be directly obtained by microbial fermentation. Poly(amino acid) superabsorbent polymers (SAPs)...
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Physiological Role of D-amino Acids and Bioanalytical Potential of D-amino Acid Oxidases
AbstractD-amino acid oxidase (DAAO) plays an important role in the functioning of both prokaryotes and eukaryotes. DAAO is increasingly being used in...
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Nutritional evaluation, amino acid, and fatty acid properties of boiled ackee arils
Ackee fruit ( Blighia sapida ) is a tropical plant widely cultivated for its delicious and nutritious arils. However, due to the presence of toxic...
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Preparation and characterization of whey-less lighvan cheese: physicochemical, textural, fatty acid, and amino acid profile changes during ripening
The purpose of this study was to produce whey-less Lighvan cheese (WLC) and characterize the cheese’s physical, chemical, and textural...
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Genome-Wide Screen for Enhanced Noncanonical Amino Acid Incorporation in Yeast
Expanding the genetic code beyond the 20 canonical amino acids enables access to a wide range of chemical functionality that is inaccessible within...
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Amino Acids, Amino Acid Derivatives and Peptides as Antioxidants
The biological concept of antioxidant refers to any compound that is able to delay or prevent the oxidation of easily oxidizable substrates, such as...
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Reversing the directionality of reactions between non-oxidative pentose phosphate pathway and glycolytic pathway boosts mycosporine-like amino acid production in Saccharomyces cerevisiae
BackgroundMycosporine-like amino acids (MAAs) are a class of strongly UV-absorbing compounds produced by cyanobacteria, algae and corals and are...
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Microbial Production of Dicarboxylates: Succinic Acid, Malic Acid, and Itaconic Acid
To establish a bio-based economy, suitable biomass-derived platform chemicals have to be identified, which can be an alternative for their...
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Insight into de-regulation of amino acid feedback inhibition: a focus on structure analysis method
Regulation of amino acid’s biosynthetic pathway is of significant importance to maintain homeostasis and cell functions. Amino acids regulate their...
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From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris
BackgroundExpansion of the genetic code is a frequently employed approach for the modification of recombinant protein properties. It involves...
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Reduction of Bacterial Folic Acid Production and Cell Membrane Disruption of Klebsiella pneumoniae by Two Amino Substituted Pyridyl Compounds: An Experimental and In Silico Approach
As bacterial resistance increases, more effective antibiotics are needed, necessitating drug discovery research. Therefore, in this paper we discuss...
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How animal milk and plant-based alternatives diverge in terms of fatty acid, amino acid, and mineral composition
The decline in fresh milk in the Western world has in part been substituted by an increased consumption of plant-based beverages (PBB). These are...
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Dual Effect of Amino Acid Compositions on Antibacterial Activity of Human Neutrophilic Granulocytes
Abstract —It is known that amino acid compositions for parenteral nutrition exhibit an immunomodulatory effect on T and B lymphocytes and phagocytes. T...
