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Green Synthesis of AuNPs and Their Effect on Cell Apoptosis of HepG2 cells for Applications in Treatment of Hepatocellular Carcinoma in Nursing Care
Recently, metal nanoparticles synthesized by bio-fabrication methods were being used for various life-saving treatments. In our present study, AuNPs...
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Initiation of Apoptotic Pathway by the Cell-Free Supernatant Synthesized from Weissella cibaria Through In-Silico and In-Vitro Methods
Globally, colorectal cancer is the most prevalent type of cancer. Even though multiple treatments such as surgery, radiation, chemotherapy, and...
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Fluorine-free synthesis of Ti3C2 MQDs for smartphone-based fluorescent and colorimetric determination of acetylcholinesterase and organophosphorus pesticides
Ti 3 C 2 MQDs were synthesized using an effective fluorine-free method with excitation/emission maxima at 390/490 nm and a fluorescence quantum yield of...
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Identification of Bioactive Pentacyclic Triterpenoids and Fatty Acid Derivatives from Cissus quadrangularis and C. rotundifolia Through Untargeted Metabolite Profiling
Comparative metabolite profiling of crude extracts of leaf and stem of two medicinally important species of genus Cissus was performed. Gas...
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The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies
BackgroundCytochrome P450s (CYPs) are a class of hemoproteins involved in drug metabolism. It has been reported that body composition, proportion of...
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Development of aromatic ethers as solvents for a calix[6]arene derivative and extraction of amino acids and proteins
Calixarene derivatives are excellent host compounds for ionic species in liquid–liquid extraction. However, many studies using calixarene derivatives...
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Ti3C2Tx-rGO-chitosan-based microcatheter sensor for real-time continuous monitoring of propofol: toward improved anesthetic management
AbstractWe are aiming to develop an electrochemical microcatheter sensor for the detection and real-time continuous monitoring of propofol (PPF),...
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Large-scale evaluation of cytochrome P450 2C9 mediated drug interaction potential with machine learning-based consensus modeling
Cytochrome P450 (CYP) enzymes play an important role in the metabolism of xenobiotics. Since they are connected to drug interactions, screening for...
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Fungal Enzymes in Bioremediation of Environmental Pollutants
The fungi grow in diverse habitats and potentially secrete an array of extracellular enzymes capable of decomposing matter. The fungal enzymes...
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Cytochrome P450 oxidase SlgO1 catalyzes the biotransformation of tirandamycin C to a new tirandamycin derivative
In the present study, an Escherichia coli whole cell system with overexpression of a cytochrome P450 oxidase SlgO1 involved in streptolydigin...
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Engineering Streptomyces sp. CPCC 204095 for the targeted high-level production of isatropolone A by elucidating its pathway-specific regulatory mechanism
BackgroundIsatropolone A and C, produced by Streptomyces sp. CPCC 204095, belong to an unusual class of non-benzenoid aromatic compounds and contain...
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Exploration of New Nickel and Copper(II) Complexes as Potential P53/Caspase 9 Activator in Human Colon Cancer Cell Line
AbstractThe two new complexes, namely [NiU 2 (H 2 O) 2 ]SO 4 , (NiU) and [CuU 2 (H 2 O) 2 ]SO 4 , (CuU) [U = 5,6-diamino-1,3-dimethyl-2,4(1 H ,3 H )-pyrimidinedione...
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Development of real-time PCR method for rapid and accurate detection of Centipedes (Scolopendra mutilans) in food
Centipedes contain pharmacologically active compounds used as important medicinal material. However, the poisons produced by centipedes can cause...
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Late-stage C–H functionalization offers new opportunities in drug discovery
Over the past decade, the landscape of molecular synthesis has gained major impetus by the introduction of late-stage functionalization (LSF)...
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Methods for the Analysis of Arachidonic Acid-Derived Metabolites in Platelets
Arachidonic acid (AA) is the precursor of a series of bioactive lipids with relevant cell signaling and pathophysiological actions. Arachidonic acid...
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A triple-channel sensing array for protein discrimination based on multi-photoresponsive g-C3N4
Graphitic carbon nitride (g-C 3 N 4 ) as an outstanding photoresponsive nanomaterial has been widely used in biosensing. Other than the conventional...
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Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering
Indole alkaloids have attracted considerable attention from synthetic chemists and biochemists for their structural diversity and important...
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Evaluation of cell wall-associated direct extracellular electron transfer in thermophilic Geobacillus sp.
In this study, a cell wall-associated extracellular electron transfer (EET) was determined in the thermophilic Geobacillus sp. to utilize iron as a...
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Development of novel isothermal-based DNA amplification assay for detection of pig tissues in adulterated meat
For the first time, we describe an innovative polymerase spiral reaction (PSR) assay for the rapid, simple, and accurate detection of pig tissues or...
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Design of a Novel Electrochemical Aptasensor Based on Molybdenum Disulfide Nanosheets for Lysozyme Detection
The precise detection of lysozyme plays a crucial role in early diagnosis of kidney failure in leukemia patients. Herein, we designed an...
