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Investigations into the concentration and metabolite profiles of stanozolol and LGD-4033 in blood plasma and seminal fluid using liquid chromatography high-resolution mass spectrometry
Potential scenarios as to the origin of minute amounts of banned substances detected in do** control samples have been a much-discussed problem in...
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EquiCP: Targeted Single-Cell Proteomics by Mass Spectrometry with Isobaric Labeled Multiplexing
Nontargeted single-cell proteomics analysis by mass spectrometry with sample multiplexing utilizing isobaric labeling is often performed using a...
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Differentiation of steroid isomers by steroid analogues adducted trapped ion mobility spectrometry-mass spectrometry
Steroids are one of the important indicators of health and disease. However, due to the high similarity of steroid structures, there are several...
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A Study of the Metabolism of Ibutamoren (MK-677), a Growth Hormone Secretagogue, in Human Urine by Ultra-High-Performance Liquid Chromatography–High-Resolution Mass Spectrometry
AbstractThe metabolism of Ibutamoren (MK-677), a nonpeptide growth hormone secretagogue, was investigated by analyzing human urine samples collected...
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Analysis and Identification of Peptide Postbiotics by LC-MS, MALDI-TOF Mass Spectrometry
The systematic examination of protein identity, amount, and function is known as proteomics. The proteome is a complex and dynamic structure, in...
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Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital
Pentobarbital is a short-acting barbiturate with anticonvulsant and sedative-hypnotic properties. Pentobarbital may be used to induce sedation,...
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Mass Spectrometry and Mass Spectrometry Imaging-based Thyroid Cancer Analysis
Thyroid carcinoma is one of the most common endocrine malignant diseases worldwide. With the rapid development of medical technology, early and...
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Spatially Resolved Quantitation of Drug in Skin Equivalents Using Mass Spectrometry Imaging (MSI)
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has seen a growing interest as a leading technique in the...
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Analysis of complex drugs by comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry: detailed chemical description of the active pharmaceutical ingredient sodium bituminosulfonate and its process intermediates
The European pharmacopeia provides analytical methods for the chemical characterization of active pharmaceutical ingredients (APIs). However, the...
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Two-Dimensional Liquid Chromatography–Mass Spectrometry: Heart-Cutting Hydrogen/Deuterium Exchange as a Tool for Small Molecule Structure Elucidation
High resolution and tandem mass spectrometry are popular techniques for the structure elucidation of small molecule impurities and metabolites....
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DGet! An open source deuteration calculator for mass spectrometry data
DGet! is an open-source analysis package written in Python for calculating the degree of deuterium enrichment in isotopically labelled molecules...
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Microbial Metabolites Annotation by Mass Spectrometry-Based Metabolomics
Since the discovery of penicillin, microbial metabolites have been extensively investigated for drug discovery purposes. In the last decades,...
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Development and application of an in-house library and workflow for gas chromatography–electron ionization–accurate-mass/high-resolution mass spectrometry screening of environmental samples
This work presents an optimized gas chromatography–electron ionization–high-resolution mass spectrometry (GC-EI-HRMS) screening method. Different...
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Nanomaterial Assisted Exosome Analysis Using Mass Spectrometry
Exosomes, extracellular vesicles (EVs) that play crucial roles in biological processes, have emerged as attractive targets for noninvasive disease...
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Improving Resolution of Isomeric Flavonoids and Their Glycosides Using Two-Dimensional Liquid Chromatography Coupled With High-Resolution Mass Spectrometry
The separation of isomers is one of the key issues in analysing complex natural matrices, thus commanding a higher separating power from the applied...
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MS1-Based Data Analysis Approaches for FFPE Tissue Imaging of Endogenous Peptide Ions by Mass Spectrometry Histochemistry (MSHC)
Ambiguous reports in the literature exist regarding the use and usefulness of formalin-fixed paraffin-embedded (FFPE) tissues in mass spectrometry...
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Development of a scoring parameter to characterize data quality of centroids in high-resolution mass spectra
High-resolution mass spectrometry is widely used in many research fields allowing for accurate mass determinations. In this context, it is pretty...
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Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology
Mass spectrometry (MS) coupled with liquid chromatography (LC) or gas chromatography (GC) has been proven to be a powerful platform in research and...
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Study of the Telomerization Reaction of Isoprene with Methanol Catalyzed by N-Heterocyclic Carbene Pd(II) Complexes Using Mass Spectrometry and NMR Spectrometry
AbstractA combination of electrospray ionization, matrix-assisted laser desorption/ionization and gas chromatography–mass-spectrometry (GC–MS) with...
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Single ion mobility monitoring (SIM2) stitching method for high-throughput and high ion mobility resolution chiral analysis
Chiral analysis is of high interest in many fields such as chemistry, pharmaceuticals and metabolomics. Mass spectrometry and ion mobility...
