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Structure-based drug design and molecular dynamics studies of an allosteric modulator targeting the protein–protein interaction site of PDK1
ContextProtein–protein interaction interfaces play a major role in cell signaling pathways. There is always a great interest in develo**...
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Protein-Based Scaffolds for Musculoskeletal Tissue Repair and Regeneration
The musculoskeletal system, a main structure of the human body, plays a crucial role in movement, safeguarding internal organs, supporting the...
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Prebiotic inulin ameliorates SARS-CoV-2 infection in hamsters by modulating the gut microbiome
Current treatment options for COVID-19 are limited, with many antivirals and immunomodulators restricted to the most severe cases and preventative...
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Plant Protein Based Beverages
Recent food industrial and research trends showed that the scientist’s focus is now shifted from basic food role to the indispensable action of...
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Application of the CRISPR/Cas9 Gene Editing Method for Modulating Antibody Fucosylation in CHO Cells
Genetic engineering plays an essential role in the development of cell lines for biopharmaceutical manufacturing. Advanced gene editing tools can...
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Roles of anti- and pro-oxidant potential of cinnamic acid and phenylpropanoid derivatives in modulating growth of cultured cells
Cinnamic acid (CiA) and phenylpropanoid derivatives are widely distributed in plant foods. In this study, anti- and pro-oxidant properties of the...
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Hsa_circular RNA_0045474 Facilitates Osteoarthritis Via Modulating microRNA-485-3p and Augmenting Transcription Factor 4
Circular RNA (circRNA) influences on the pathological process of osteoarthritis (OA) and may be a potential marker for disease diagnosis. The study...
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Impact of Green Extraction Technologies on Plant Protein Content and Quality
Protein is a vital component of a healthy diet and products derived from plant-based protein sources are being produced and consumed at an increasing...
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Systematic discovery of biomolecular condensate-specific protein phosphorylation
Reversible protein phosphorylation is an important mechanism for regulating (dis)assembly of biomolecular condensates. However, condensate-specific...
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Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase-1 pathway and gut microbiota in mice model
Bisphenol A has become a global public health problem. As an antioxidant, geraniol has potential preventive effects against toxicity. This study...
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Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications
The non-structural protein 5 (NS5) is the most conserved protein among flaviviruses, a family that includes the dengue virus. It functions both as an...
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Blended-protein changes body weight gain and intestinal tissue morphology in rats by regulating arachidonic acid metabolism and secondary bile acid biosynthesis induced by gut microbiota
PurposeThe impact of dietary nutrients on body growth performance and the composition of gut microbes and metabolites is well-established. In this...
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Lemon fermented products prevent obesity in high-fat diet-fed rats by modulating lipid metabolism and gut microbiota
Citrus limon (lemon) possesses immunoregulatory, antioxidant, and lipid-lowering effects. Our previous study showed that lemon fermented products...
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Electrochemical properties and slow release properties of Mung bean protein gel
This study investigates the influence of Ca 2+ on the electrochemical properties and performance of catechin-loaded mung bean protein hydrogels. Our...
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Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation has important implications for analysing cellular function,...
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MiRNA-30a-5p/VCAN Arrests Tumor Metastasis via Modulating the Adhesion of Lung Adenocarcinoma Cells
Previous research indicated that the dysregulation of miRNA-30a-5p has a correlation with cell metastasis of lung adenocarcinoma (LUAD). But the...
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Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4
Unlocking the potential of protein arginine deiminase 4 (PAD4) as a drug target for rheumatoid arthritis requires a deeper understanding of its...
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Propofol suppresses non-small cell lung cancer progression by modulating circ_0001727/miR-516b-5p/LRRC1 axis
BackgroundPropofol plays an anti-cancer role in diverse cancers, including non-small cell lung cancer (NSCLC). We aimed to study the function and...
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Modulating of microencapsulated virgin coconut oil-based creamer
This work aims to produce a virgin coconut oil (VCO) creamer through two drying stages; spray drying followed by fluidised bed drying, and to examine...
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Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence
IntroductionThis umbrella review aimed to investigate the evidence of an effect of dietary intake of total protein, animal and plant protein on blood...
