Search
Search Results
-
Study on hyperspectral monitoring model of β-glucan content in oat grains
The β-glucan in oat grain plays an important role in preventing cardiovascular disease. Therefore, it is of great significance to realize the rapid...
-
Identification of novel NLRP3 inhibitors: a comprehensive approach using 2D-QSAR, molecular docking, molecular dynamics simulation and drug-likeness evaluation
This research, employing computational methodologies, aimed to discover potential inhibitors for the nucleotide-binding oligomerization domain-like...
-
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production
In the effort to generate sustainable clean energy from abundant resources such as water and carbon dioxide, solar fuel production—the combination of...
-
Generation of Arming Yeasts with Active Proteins and Peptides via Cell Surface Display System: Cell Surface Engineering, Bio-Arming Technology
The cell surface display system in yeast enables the innovative strategy for improving cellular functions in a wide range of applications such as...
-
Photoiniferter-Driven Precision Surface Graft Microarchitectures for Biomedical Applications
The photoiniferter polymerization method proposed by Otsu et al. was utilized to generate well-controlled graft polymer chains on a surface. The...
-
Quantitation of Purine in Urine by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
Inborn errors of purine metabolism, either deficiencies of synthesis or catabolism pathways, lead to a wide spectrum of clinical presentations:...
-
Emerging Role of Structural and Systems Biology in Anticancer Therapeutics
Structural biology methods presently play a significant role in the development of new therapeutic drugs such as approaches for cancer therapies....
-
A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition
DNA-encoded chemical libraries (DELs) consist of large chemical compound collections individually linked to DNA barcodes, facilitating pooled...
-
Single-holed cobalt − nitrogen − carbon hollow structure with oxidase-mimicking activity for the chemiluminescence determination of β − galactosidase activity
A single-holed cobalt − nitrogen − carbon (Co − N − C) hollow structure nanozyme has been fabricated by in situ growth of zeolitic imidazolate...
-
Design of label-free electrochemical aptasensors for enrofloxacin detection in mutton
A label-free electrochemical aptasensor was developed using a 3D porous chitosan-reduced graphene oxide nanocomposite matrix for rapid and...
-
De novo development of small cyclic peptides that are orally bioavailable
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical...
-
Quantitation of Pyrimidine in Urine by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
Inborn errors of pyrimidine metabolism result from deficiencies in pyrimidine de novo synthesis, degradation, and salvage pathways. Enzymatic...
-
Enhancing antibody affinity through experimental sampling of non-deleterious CDR mutations predicted by machine learning
The application of machine learning (ML) models to optimize antibody affinity to an antigen is gaining prominence. Unfortunately, the small and...
-
Adsorbed cobalt porphyrins act like metal surfaces in electrocatalysis
Electrodes chemically modified with molecular active sites are potent catalysts for energy conversion reactions. Such electrodes are typically...
-
Quantitation of Phenylalanine in Dried Blood Spot Using Liquid Chromatography Tandem Mass Spectrometry for Monitoring of Patients with Phenylketonuria (PKU)
Newborn screening for phenylketonuria (PKU) is performed by analysis of phenylalanine in dried blood spot (DBS). Once diagnosed by a definitive...
-
Development of a novel strategy for robust synthetic bacterial promoters based on a stepwise evolution targeting the spacer region of the core promoter in Bacillus subtilis
BackgroundPromoter evolution by synthetic promoter library (SPL) is a powerful approach to development of functional synthetic promoters to synthetic...
-
A CRISPR-Cas12a-based electrochemical biosensor for the detection of microphthalmia-associated transcription factor
A novel electrochemical biosensor that combines the CRISPR-Cas12a system with a gold electrode is reported for the rapid and sensitive detection of...
-
Quantum sensing of microRNAs with nitrogen-vacancy centers in diamond
Label-free detection of nucleic acids such as microRNAs holds great potential for early diagnostics of various types of cancers. Measuring intrinsic...
-
Metabolic engineering of Escherichia coli for the production of 5-aminolevulinic acid based on combined metabolic pathway modification and reporter-guided mutant selection (RGMS)
Background5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition...
-
Harnessing Heterocycles: Fine-Tuning Furan-Pyridine Amidines for Precision Anticancer Therapy
AbstractTwo new dichlorophenylfurylnicotinamidine regioisomers and were prepared from the corresponding dichlorophenylfurylnicotinonitriles when...
