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Graphene oxide composites for magnetic solid-phase extraction of twelve quinolones in water samples followed by MALDI-TOF MS
Antibiotic compounds in natural waters are normally present at low concentrations. In this paper, an easy and highly sensitive screening method using...
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Nucleophilic substitution of a 4-dimethylamino group in quinoline proton sponges. Stabilization of 4-quinolones in hydroxy form. Synthesis of a proton sponge based on 8-hydroxyquinoline
Demethylation of methoxy groups in 6(8)-methoxy-2,4,5-tris(dimethylamino)quinolines with 48% HBr leads to nucleophilic substitution of the 4-NMe 2 ...
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Novel and simple analytical method for simultaneous determination of sulfonamide, quinolone, tetracycline, macrolide, and chloramphenicol antibiotics in soil
The multiclass determination of antibiotic residues in the soil is challenging because of its complex physicochemical properties. In this study, a...
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Assessment of the stability of antimicrobials and resistance genes during short- and long-term storage condition: accounting for uncertainties in bioanalytical workflows
Unravelling complexities in antimicrobial agent–microbe interactions in the context of antimicrobial resistance (AMR) requires robust analytical...
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Role of Trifluoromethyl Substitution in Design of Antimalarial Quinolones: a Comprehensive Review
Malaria represents a significant health issue, and novel effective drugs are needed to address parasite resistance that has emerged to the current...
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Antibiotic Drug Resistance
AntibioticsAntibiotics inhibit the growth or reproduction of microbes, enabling immune system and other defense mechanisms to finish their task....
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γ-Cyclodextrin-graphene quantum dots-chitosan modified screen-printed electrode for sensing of fluoroquinolones
An innovative electrochemical approach based on screen-printed carbon electrodes (SPCEs) modified with graphene quantum dots (GQDs) functionalized...
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Production of quinolone derivatives in Escherichia coli
Alkyl-4-quinolones (AQs) are natural compounds synthesized by bacteria. Members of this group are known quorum-sensing molecules. Other biological...
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Determine Multiple Classes of Veterinary Antibiotics in Soil: Comparing Dispersive and Solid-Phase Extraction for Sample Cleanup
Veterinary antibiotics in agricultural soil are a growing concern, as they pose risks to soil quality and food safety. An analysis approach that...
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Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones
The strong antibacterial, antiviral and anticancer activities demonstrated by quinolones make them promising lead structures and important synthetic...
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Improving sorption performance of a molecularly imprinted monolithic column by do** mesoporous molecular sieve SBA-15
For the first time a hybrid molecularly imprinted polymer (MIP) doped with 3-(trimethoxysilyl) propyl methacrylate (γ-MPS)-modified mesoporous...
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Using Hypercrosslinked Polystyrene for the Multicomponent Solid-Phase Extraction of Residues of 63 Veterinary Preparations in Their Determination in Chicken Meat by High-Performance Liquid Chromatography–Tandem Mass Spectrometry
AbstractHypercrosslinked polystyrene is proposed for the multicomponent solid-phase extraction of residues of 63 veterinary preparations from various...
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Chemometric−Assisted QuEChERS Method for Multiresidue Analysis of Veterinary Drugs in Pigeon Muscle by LC-MS/MS
Pigeon is an essential poultry with tasty meat and high protein content, and its breeding and consumption of meat have been increasing annually....
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Development and Evaluation of a Preliminary Screening Assay for Antibiotic Residues in Meat
A preliminary screening assay based on a microbial chromogenic reaction was developed to detect common antibiotic residues in meat rapidly. The assay...
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Multiresidue method for the determination of critically and highly important classes of antibiotics and their metabolites in agricultural soils and sewage sludge
In this paper, a method is proposed for the determination of antibiotics classified by the World Health Organization as critically important (four...
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Magneto Immunofluorescence Assay for Quinolone Detection in Bovine Milk
Quinolone is a family of widely prescript antibiotics in veterinary medicine. Their excessive use can be causative of quinolone residues in...
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Using differential ion mobility spectrometry to perform class-specific ion-molecule reactions of 4-quinolones with selected chemical reagents
Gas phase ion/molecule reactions are often used in analytical applications to support the analysis of isomers or to identify specific functional...
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The New Antibacterial Agents Based on the Fused Aromatic Heterocyclic Compounds: Design, Synthesis, and Antibacterial Activity
AbstractIn this study, the reaction of 1-alkyl-5-nitro-1 H -benzoimidazoles and 1-alkyl-5-nitro-1 H -indazoles with benzofuran and benzothiophen...
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Framework for evaluation of food safety in the circular food system
In order to minimise food waste, side streams from feed and food production are increasingly being (re-) used in food supply chains. Such reuse...
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Antibiotics That Inhibit Nucleic Acid Synthesis
Antibiotics that inhibit the synthesis of nucleic acids including DNA and RNA are presented. Background biochemistry information on the structure of...