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Minimum latency effects for cancer associated with exposures to radiation or other carcinogens
BackgroundIn estimating radiation-associated cancer risks a fixed period for the minimum latency is often assumed. Two empirical latency functions...
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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Human cytomegalovirus DNA detection in a recurrent glioblastoma multiforme tumour, but not in whole blood: a case report and discussion about the HCMV latency and therapy perspectives
In the current study, a 58-year-old male patient presented with recurrent glioblastoma multiforme (GBM). The patient underwent surgical resection,...
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SETDB1 tumour suppressor roles in near-haploid mesothelioma involve TP53
BackgroundMutational inactivation of the SETDB1 histone methyltransferase is found in a subset of mesothelioma, particularly in cases with...
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C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer
BackgroundThis study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric...
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Role of Tumour-Associated Macrophages in Colon Cancer Progression and Its Therapeutic Targeting
Cancer tissues are invariably infiltrated by cells of the immune system, and macrophages constitute the major portion of these. Experimental pieces...
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Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment. KLKs are proteolytic enzymes regulating multiple...
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Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?
Two fields of cancer research have emerged dealing with the biology of tumour cells localised to the abluminal vascular surface: vessel co-option...
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The role of ROS in tumour development and progression
Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control...
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Presence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study
The mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus,...
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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker
Immune-checkpoint inhibitors have shown modest efficacy against immunologically ‘cold’ tumours. Interleukin-12 (IL-12)—a cytokine that promotes the...
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Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival
BackgroundWhile cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and...
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Immunomodulation by radiotherapy in tumour control and normal tissue toxicity
Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than half of all patients with cancer. In addition to the...
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ROS and TGFβ: from pancreatic tumour growth to metastasis
Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and...
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Prostate cancer genetic propensity risk score may modify the association between this tumour and type 2 diabetes mellitus (MCC-Spain study)
BackgroundSome studies have reported an inverse association between type 2 diabetes mellitus (T2DM) and prostate cancer (PCa), but results on this...
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Autophagy and Tumour Chemotherapy
Chemotherapy is an important means of treating malignant tumours. The main role of chemotherapy drugs is to induce cell death. However, the apoptotic...
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Maternal and childhood medical history and the risk of childhood brain tumours: a case–control study in Ontario, Canada
BackgroundStudies to date have yielded inconclusive results as to whether maternal medical history during pregnancy, and a child’s early-life medical...
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Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program
BackgroundThe Tumor Microenviroment (TME) is a complex milieu that is increasingly recognized as a key factor in multiple stages of disease...
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Hypoxia and the Metastatic Cascade
Metastasis is a leading cause of mortality in cancer patients. The journey of a detached primary tumour cell to a secondary homing site is a...
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Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model
ObjectiveThere is substantial evidence that exercise can safely reduce the risk of cancer and improve survival in different human cancer populations....
