Abstract
Chemotherapy is an important means of treating malignant tumours. The main role of chemotherapy drugs is to induce cell death. However, the apoptotic pathways of many tumour cells are often severely impaired, leading to failure of chemotherapy-induced apoptosis. With the in-depth study of autophagy in recent years, this process has been found to play an important role in the chemoresistance of tumours. Autophagy may have different effects on tumour cells depending on the specific environment. In addition, tumour stem cells and the tumour microenvironment are closely related to tumour recurrence and metastasis. It is also important to study the role of autophagy in tumour stem cells and the microenvironment to investigate chemotherapy resistance.
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References
Bishnu A, Sakpal A, Ghosh N et al (2019) Long term treatment of metformin impedes development of chemoresistance by regulating cancer stem cell differentiation through taurine generation in ovarian cancer cells. Int J Biochem Cell Biol 107:116–127
Drake LE, Springer MZ, Poole LP et al (2017) Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol 47:110–124
Fitzwalter BE, Towers CG, Sullivan KD et al (2018) Autophagy inhibition mediates apoptosis sensitization in cancer therapy by relieving FOXO3a turnover. Dev Cell 44(555–565):e3
Galluzzi L, Bravo-San Pedro JM, Levine B et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov 16:487–511
Huang T, Kim CK, Alvarez AA et al (2017) MST4 phosphorylation of ATG4B regulates autophagic activity, tumorigenicity, and radioresistance in glioblastoma. Cancer Cell 32(840–855):e8
Huang S, Qi P, Zhang T et al (2018) The HIF1alpha/miR2243p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxiainduced protective autophagy in glioblastoma and astrocytoma. Oncol Rep
Kaverina N, Borovjagin AV, Kadagidze Z et al (2017) Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy. Autophagy 13:1905–1923
La Noce M, Paino F, Mele L et al (2018) HDAC2 depletion promotes osteosarcoma’s stemness both in vitro and in vivo: a study on a putative new target for CSCs directed therapy. J Exp Clin Cancer Res 37:296
Lee MH, Koh D, Na H et al (2018) MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Autophagy 14:812–824
Levy JMM, Towers CG, Thorburn A (2017) Targeting autophagy in cancer. Nat Rev Cancer 17:528–542
Li B, Cao Y, Meng G et al (2019) Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway. EBioMedicine 39:239–254
Lin SJ, Wu ZR, Cao L et al (2017) Pituitary tumor suppression by combination of cabergoline and chloroquine. J Clin Endocrinol Metab 102:3692–3703
Nguyen TD, Shaid S, Vakhrusheva O et al (2018) Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood
Noman MZ, Berchem G, Janji B (2018) Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield. Autophagy 14:730–732
Peng Q, Qin J, Zhang Y et al (2017) Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2. J Exp Clin Cancer Res 36:171
Pindiprolu S, Krishnamurthy PT, Chintamaneni PK (2018) Pharmacological targets of breast cancer stem cells: a review. Naunyn Schmiedebergs Arch Pharmacol 391:463–479
Piya S, Andreeff M, Borthakur G (2017) Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia. Autophagy 13:214–215
Sun L, Hu L, Cogdell D et al (2017) MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Autophagy 13:703–714
Tang ZH, Cao WX, Guo X et al (2018) Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Lett 412:1–9
Tuomela J, Sandholm J, Kauppila J et al (2013) Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett 6:1665–1672
Verbaanderd C, Maes H, Schaaf MB et al (2017) Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer agents. Ecancermedicalscience 11:781
Wang Q, Zeng F, Sun Y et al (2018) Etk interaction with PFKFB4 modulates chemoresistance of small-cell lung cancer by regulating autophagy. Clin Cancer Res 24:950–962
Yang H, Zheng Y, Zhang Y et al (2017) Mesenchymal stem cells derived from multiple myeloma patients protect against chemotherapy through autophagy-dependent activation of NF-kappaB signaling. Leuk Res 60:82–88
Yu T, Guo F, Yu Y et al (2017) Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell 170(548–563):e16
Yuan J, Zhang N, Yin L et al (2017) Clinical implications of the autophagy core gene variations in advanced lung adenocarcinoma treated with gefitinib. Sci Rep 7:17814
Zhang H, McCarty N (2017) Tampering with cancer chemoresistance by targeting the TGM2-IL6-autophagy regulatory network. Autophagy 13:627–628
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Hou, X., Jiang, J., Tian, Z., Wei, L. (2020). Autophagy and Tumour Chemotherapy. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_24
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DOI: https://doi.org/10.1007/978-981-15-4272-5_24
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