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Anti-Drug Antibody Incidence Comparison of Therapeutic Proteins Administered Via Subcutaneous vs. Intravenous Route
Subcutaneous (SC) administration of therapeutic proteins is perceived to pose higher risk of immunogenicity when compared with intravenous (IV) route...
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Δ9-Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
The physiological impact of cannabinoid receptor agonists is of great public health interest due to their increased use in recreational and...
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Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route
Because of their high specificity, high affinity, and targeting, antibody drugs have been widely used in the treatment of many diseases and have...
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Polycaprolactone microparticles for the subcutaneous administration of cannabidiol: in vitro and in vivo release
Cannabidiol (CBD) has become a highly attractive entity in therapeutics. However, its low aqueous solubility, instability and handling problems limit...
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Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access
In recent years, subcutaneous administration of biotherapeutics has made significant progress. The self-administration market for rheumatoid...
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Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease
The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment...
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Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel
PurposeSystemic absorption is the process of drug movement from the site of drug administration to systemic circulation for therapeutic efficacy....
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Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration
Multiple FDA-approved and clinical-development stage therapeutics include recombinant human hyaluronidase PH20 (rHuPH20) to facilitate subcutaneous...
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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors
BackgroundCranial nerve-related diseases such as brain tumors, Alzheimer’s disease, and epilepsy are serious diseases that continue to threaten...
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In-line warming reduces in-line pressure of subcutaneous infusion of concentrated immunoglobulins
Immunoglobulin replacement therapy is a life-saving treatment in patients with immunodeficiency and effective in the management of autoimmune...
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Understanding the Routes of Administration
Routes of administration are the key determinant to ensuring therapeutic benefits of the drug. The choice of route of drug delivery is vastly...
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Effect of subcutaneous vs. intravenous tocilizumab in patients with severe COVID-19: a systematic review
ObjectiveTo systematically evaluate the efficacy of subcutaneous tocilizumab in the treatment of patients with severe COVID-19 and provide evidence...
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Routes of Drug Administration
The systemic absorption of a drug depends on its physicochemical properties, the nature of the dosage form on which it is included, and the...
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Nanomedicines via the pulmonary route: a promising strategy to reach the target?
Over the past decades, research on nanomedicines as innovative tools in combating complex pathologies has increased tenfold, spanning fields from...
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A Perspective on Model-Informed IVIVC for Development of Subcutaneous Injectables
Subcutaneously administered drugs are growing in popularity for both large and small molecule drugs. However, development of these systems –...
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Activation dynamics of antigen presenting cells in vivo against Mycobacterium bovis BCG in different immunized route
BackgroundControl of Tuberculosis (TB) infection is mainly the result of productive teamwork between T-cell populations and antigen presenting cells...
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Imaging of large volume subcutaneous deposition using MRI: exploratory clinical study results
Subcutaneous (SC) delivery is a preferred route of administration for biotherapeutics but has predominantly been limited to volumes below 3 mL. With...
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Subcutaneous Xenograft Models for Studying PDT In Vivo
The most facile, reproducible, and robust in vivo models for evaluating the anticancer efficacy of photodynamic therapy (PDT) are subcutaneous...