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Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images
In this protocol, we describe the specific steps required to prepare human postmortem brain samples for ultrastructural microglial analysis. A...
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Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice
Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made...
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Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To...
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Microglia/macrophages are ultrastructurally altered by their proximity to spinal cord injury in adult female mice
Traumatic spinal cord injury can cause immediate physical damage to the spinal cord and result in severe neurological deficits. The primary,...
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Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization
The pathogenicity of quartz involves lysosomal alteration in alveolar macrophages. This event triggers the inflammatory cascade that may lead to...
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Therapeutic treatment of dietary docosahexaenoic acid for particle-induced pulmonary inflammation in Balb/c mice
Objective and designThe omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been reported to suppress inflammation. Pulmonary...
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Introduction to Pharmacology of Macrophages with Drug Delivery Perspective
Ubiquitously present macrophages are an integral member of the innate immune system and are crucially involved in host defense and homeostasis. They...
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Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory lesions and associated neural dysfunctions. In multiple...
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Chlamydia and Chlamydophila
The taxonomy of Chlamydia has undergone extensive revision recently based on genomic studies of this microorganism. They are included in the family...
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Study of the Morphogenesis of Granulomas in the Liver of Mice in Different Age Periods Treated with Oxidized Dextran
We studied granuloma formation and its outcomes in BCG-induced granulomatosis in the liver of mice of different age periods treated with oxidized...
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Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (MΦs) has been recently described as an unconventional role of...
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Host genetic susceptibility underlying SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Brazilian Children
BackgroundMultisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2...
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Exploring and exploiting the host cell autophagy during Mycobacterium tuberculosis infection
Tuberculosis, caused by Mycobacterium tuberculosis , is a fatal infectious disease that prevails to be the second leading cause of death from a single...
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Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF–SIMS analysis
The detection of biomedical organic nanocarriers in cells and tissues is still an experimental challenge. Here we developed an imaging strategy for...
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Renal protein reabsorption impairment related to a myxosporean infection in the grass frog (Rana temporaria L.)
A morphophysiological study of tubular reabsorption and mechanisms of protein endocytosis in the kidney of frogs ( Rana temporaria L.) during...
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Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19
BackgroundHypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies...
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Antimycobacterial Attributes of Mitochondria: An Insight into Host Defense Mechanisms
Tuberculosis (TB) is a major global health problem caused by Mycobacterium tuberculosis (MTB). According to the World Health Organization (WHO),...
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IFN-induced cell-autonomous immune mechanisms in the control of intracellular protozoa
Vertebrate cells have evolved an elaborate multi-tiered intracellular surveillance system linked to downstream antimicrobial effectors to defend...
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Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective
Macrophages are myeloid immune cells which present in most of the tissues of the body and have various functions in almost every aspect of mammalian...
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Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
Microglia, the resident immune cells of the brain, are increasingly implicated in the regulation of brain health and disease. Microglia perform...
