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A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
Worldwide, many lives have been lost in the recent outbreak of coronavirus disease. The pathogen responsible for this disease takes advantage of the...
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A review on the role of LINC01133 in cancers
Long Intergenic Non-Protein Coding RNA 1133 (LINC01133) is a long non-coding RNA (lncRNA) which interacts with miR-106a-3p, miR-576-5p, miR-495-3p,...
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Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
Background and aim"Inflammatory bowel disease" (IBD) is a chronic, relapsing inflammatory disease of the intestinal tract that typically begins at a...
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LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway
BackgroundGastric cancer (GC) is a common malignancy and frequent cause of cancer-related death. Long non-coding RNAs (lncRNAs) have emerged as...
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CircRNA ITCH Inhibits Epithelial–Mesenchymal Transformation and Promotes Apoptosis in Papillary Thyroid Carcinoma via miR-106a-5p/JAZF1 Axis
Circular RNA ITCH (circ-ITCH) is implicated in papillary thyroid carcinoma (PTC) development. Nevertheless, the more detailed molecular mechanism...
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CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a sco** review
BackgroundMedulloblastoma is one of the common primary central nervous system (CNS) malignancies in pediatric patients. The main treatment is...
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Recent advances on high-efficiency of microRNAs in different types of lung cancer: a comprehensive review
Carcinoma of the lung is among the most common types of cancer globally. Concerning its histology, it is categorized as a non-small cell carcinoma...
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The regulatory role of LncRNA HCG18 in various cancers
As a member of long non-coding RNAs (lncRNAs), LncRNA HLA complex group 18 (HCG18) has recently become the focus of cancer research. As outlined in...
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Etiology Analysis for Human Cancer
Although disease prediction by microRNAs (miRNAs) based on mathematical data science has been statistically validated, no disease prediction can...
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Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer
There is an urgent need for new and better biomarker modalities to estimate the risk of recurrence within the luminal-like breast cancer (BC)...
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Hub gene identification and immune infiltration analysis in hepatocellular carcinoma: Computational approach
In the case of hepatocellular carcinoma, there is a need to find novel immune biomarkers to predict cancer prognosis, which will help prolong patient...
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Encounter with the Unknown
The severe respiratory syndrome human coronavirus 2 (SARS-CoV-2) pandemic has forced us to recognize the need for rapid analysis of unknown viral...
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Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene
BackgroundFrom the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic...
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Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway
Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D...
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MiRNA Immunity Against Virus and MiRNA Surveillance Against Tumor
Through the microRNA (miRNA) entangling target sorting/quantum miRNA language plus artificial intelligence (METS/MIRAI) analysis so far, it seems...
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Diagnostic, Prognostic and Theranostic Potential of miRNAs in Prostate Cancer
A novel class of gene regulators, small noncoding RNAs or microRNAs (miRNAs) has an important role in various malignancies, including prostate cancer...
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Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
Liquid biopsy research on Low-Grade gliomas (LGG) has remained less conspicuous than that on other malignant brain tumors. Reliable serum markers...
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The role of natural products versus miRNA in renal cell carcinoma: implications for disease mechanisms and diagnostic markers
Natural products are chemical compounds produced by living organisms. They are isolated and purified to determine their function and can potentially...
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Role of HOXA1-4 in the development of genetic and malignant diseases
The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and exert critical functions in early embryonic development, as well as...
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miRNA Signature of Urine Extracellular Vesicles Shows the Involvement of Inflammatory and Apoptotic Processes in Diabetic Chronic Kidney Disease
BackgroundThe aim of this study was to investigate the role of urine-derived extracellular vesicles (uEVs) in diabetic kidney disease (DKD) in...
