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Novel insights into double-stranded RNA-mediated immunopathology
Recent progress in human and mouse genetics has transformed our understanding of the molecular mechanisms by which recognition of self...
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The complete genome sequences of a negative single-stranded RNA virus and a double-stranded RNA virus coinfecting the entomopathogenic fungus Beauveria bassiana Vuillemin
Beauveria bassiana Vuillemin is an entomopathogenic fungus that has been developed as a biological insecticide. B. bassiana can be infected by single...
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Removal of Double-Stranded RNA Contaminants During Template-Directed Synthesis of mRNA
The removal of double-stranded RNA (dsRNA) contaminants during in vitro mRNA synthesis is one of the technological problems to be solved. Apparently,...
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Complete genome sequence of a novel double-stranded RNA virus infecting the phytopathogenic fungus Rhizopus stolonifer
In this study, we report the complete genome sequence of a novel toti-like virus, tentatively named "Rhizopus stolonifer double-stranded RNA virus 1"...
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Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α
Hypoxia inducible factor-1α (HIF-1α) is a crucial therapeutic target in various diseases, including cancer and fibrosis. We previously demonstrated...
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Gene silencing in the aedine cell lines C6/36 and U4.4 using long double-stranded RNA
BackgroundRNA interference (RNAi) is a target-specific gene silencing method that can be used to determine gene functions and investigate...
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Characterization of tumor microenvironment and tumor immunology based on the double-stranded RNA-binding protein related genes in cervical cancer
BackgroundCervical cancer is one of the most common gynecological cancers threatening women’s health worldwide. Double-stranded RNA-binding proteins...
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Activation of Double-Stranded RNA–Activated Protein Kinase in the Dorsal Root Ganglia and Spinal Dorsal Horn Regulates Neuropathic Pain Following Peripheral Nerve Injury in Rats
Double-stranded RNA (dsRNA)–activated kinase (PKR) is an important component in inflammation and immune dysfunction. However, the role of PKR in...
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Molecular characterization of a novel non-segmented double-stranded RNA mycovirus isolated from Penicillium citrinum strain RCEF7060
Penicillium citrinum is a commonly occurring filamentous fungus with a worldwide distribution. However, no sequence data for viruses in P. citrinum ...
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Emerging role of the RNA-editing enzyme ADAR1 in stem cell fate and function
Stem cells are critical for organism development and the maintenance of tissue homeostasis. Recent studies focusing on RNA editing have indicated how...
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Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
BackgroundType 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα),...
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RNA-FISH for HIV Transcription/Localization Analysis
RNA fluorescence in situ hybridization (FISH) serves as a method for visualizing specific RNA molecules within cells. Its primary utility lies in the...
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Use of RNA Interference Technology for Improving Economically Valuable Traits of Cereal Crops
AbstractRNA interference (RNAi) is a new potential tool for plant breeding by introducing small noncoding RNA sequences with the possibility of...
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Incidence of putative RNA mycoviruses in entomopathogenic fungi in Korea
Entomopathogenic fungi have potential as biocontrol agents against insect pests, and mycovirus-mediated hypervirulence may enhance their efficacy....
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Production and Testing of RNA Origami Anticoagulants
Nucleic acid nanotechnology provides the ability to create unprecedented nanostructures with diverse architectures and functions that can be utilized...
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Viral RNA as a Branched Polymer
Myriad viruses use positive-strand RNA molecules as their genomes. Far from being only a repository of genetic material, viral RNA performs numerous...
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Epi-Drugs Targeting RNA Dynamics in Cancer
From the early discovery of ribonucleic acid in 1868, the RNA world has seen constant evolution. To date, more than ten types of RNA species are...
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From DNA to RNA
The paths to scientific discovery and innovation are notoriously complex and winding, and those that led to the discovery of DNA and messenger RNA...
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Antiviral Potency of Small Interfering RNA Molecules
Small interfering RNA (siRNA) are short (19–25 bp) double-stranded (ds) RNA molecules that in cytoplasm of eukaryotic cells triggers...
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Architecture of RNA
A single strand of RNA folds upon itself to form its many structures. The helices and loop regions formed in the secondary structures interact with...