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Altered Calcium Permeability of AMPA Receptor Drives NMDA Receptor Inhibition in the Hippocampus of Murine Obesity Models
Evidence has accumulated that higher consumption of high-fat diets (HFDs) during the juvenile/adolescent period induces altered hippocampal function...
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Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendiline and NPS R-467
Synthetic routes following a sequential MacMillan organocatalytic asymmetric α-fluorination protocol for aldehydes and then reductive amination, have...
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Impact of calcium channel blockers and angiotensin receptor blockers on hematological parameters in type 2 diabetic patients
Antihypertensive medications have been associated with a reduction in hemoglobin (Hb) levels, leading to clinically significant anemia. We aimed to...
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Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish
Aminoglycosides are commonly used antibiotics for treatment of gram-negative bacterial infections, however, they might act on inner ear, leading to...
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Iron-Calcium Crosstalk in Neurodegenerative Diseases
Iron and calcium have one thing in common: they are both required for appropriate neural activity. Neuronal calcium impulses drive neurochemical...
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Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is typically characterized by chronic intermittent hypoxia (CIH), associated with cognitive...
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Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
Insulin resistance is a major contributor to the pathogenesis of several human diseases, including type 2 diabetes, hypertension, and hyperlipidemia....
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The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function
Chronic pain has a debilitating consequences on health and lifestyle. The currently available analgesics are often ineffective and accompanied by...
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The NMDA Receptor System and Developmental Neurotoxicity
The NMDA receptor system has been implicated in the etiology of ketamine-induced developmental neurotoxicity. Prolonged ketamine exposure resulting...
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TNFα Enhances Calcium Influx by Interacting with AMPA Receptors in the Spinal Dorsal Horn Neurons
Tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine and has been implicated in pain regulation. Neuronal activity in the spinal dorsal...
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Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common type of dementia that characterizes the accumulation of amyloid-β plaques and neurofibrillary tangles in...
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Calcium Sensors of Neurotransmitter Release
Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous)....
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Regulation of Presynaptic Calcium Channels
Voltage-gated calcium channels (VGCCs), especially Cav2.1 and Cav2.2, are the major mediators of Ca2+ influx at the presynaptic membrane in response...
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Calcium imaging of adult olfactory epithelium reveals amines as important odor class in fish
The odor space of aquatic organisms is by necessity quite different from that of air-breathing animals. The recognized odor classes in teleost fish...
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Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target
Canonical or classical transient receptor potential (TRPC) proteins are nonselective cationic channels and a subset of TRP superfamily which are...
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The importance of kidney calcium handling in the homeostasis of extracellular fluid calcium
Extracellular fluid calcium concentration must be maintained within a narrow range in order to sustain many biological functions, encompassing muscle...
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Live FRET-FLIM Imaging to Study Metabotropic Signaling via the NMDA Receptor
Until recently, NMDA receptor (NMDAR) functions have been attributed to its ability to conduct calcium ions. However, growing evidence demonstrates...