Abstract
Iron and calcium have one thing in common: they are both required for appropriate neural activity. Neuronal calcium impulses drive neurochemical release, proliferation of axon and synapse formation, and govern the gene expression involved in memory formation, while, iron is essential for normal functioning of mitochondria, synapse formation, and the acquisition of cognitive skills. Latest research has discovered that cellular iron enhances calcium signalling, resulting in subsequent stimulation of kinase pathways. Moreover, iron-mediated reactive oxygen species production strengthens usual calcium-regulated signalling processes under physiological environment, whereas, elevated iron levels induces oxidative stress, which leads to an increase in uncontrolled calcium inputs that potentially harm normal functioning of mitochondria and other associated functions.
In this chapter, we will examine the facts surrounding a poorly known link between iron and calcium balance and connection, in which one’s deregulation has an affect on another, resulting in a negative feedback system that eventually leads to neurodegenerative disorders. We provides a brief account on background, homeostasis of iron and calcium and related anomalies upon imbalances occur. Also describe the crosstalk among these two i.e. iron and calcium and related cell death (ferroptosis) and their connecting links.
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We gratefully acknowledge the support provided by the Indian Council of Medical Research (ICMR), New Delhi, India [ICMR-SRF grant (No.45/35/2018-PHA/BMS)].
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Kadian, M., Sharma, G., Kumar, A. (2023). Iron-Calcium Crosstalk in Neurodegenerative Diseases. In: Mohamed, W., Brogazzi, N.L., Kostrzewa, R.M. (eds) Brain-Iron Cross Talk. Nutritional Neurosciences. Springer, Singapore. https://doi.org/10.1007/978-981-19-7327-7_6
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