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Serum neurofilament light chain and initial severity of neurological disease predict the early neurological deterioration in Wilson’s disease
BackgroundIn Wilson’s disease (WD), early neurological deterioration after treatment initiation is associated with poor outcomes; however, data on...
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Brain microstructural abnormalities in patients with Wilson’s disease: A systematic review of diffusion tenor imaging studies
IntroductionWilson’s disease (WD) is an autosomal recessive that can lead to high copper concentrations and copper accumulation in bodily organs,...
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Altered microstructural pattern of the cortex and basal forebrain cholinergic system in wilson’s disease: an automated fiber quantification tractography study
Basal forebrain (BF) cholinergic projection neurons form a highly extensive input to the cortex. Failure of BF cholinergic circuits is responsible...
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Sleep disturbances in newly diagnosed treatment-naïve patients with Wilson’s disease
IntroductionMost neurodegenerative and chronic liver disorders are associated with sleep disturbances (SD). SD may be expected to occur in patients...
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Liver transplantation as a treatment for Wilson’s disease with neurological presentation: a systematic literature review
IntroductionWilson’s disease (WD) is a potentially treatable, genetic disorder of copper metabolism, with survival similar to healthy populations if...
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Clinical and genetic characterization of a large cohort of patients with Wilson’s disease in China
BackgroundWilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B (encoding a copper-transporting P-type...
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Basal ganglia-orbitofrontal circuits are associated with prospective memory deficits in Wilson’s disease
Degenerative changes in the basal ganglia (BG) are thought to contribute to neurological symptoms in Wilson’s disease (WD). However, very little is...
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Carrier screening for present disease prevalence and recessive genetic disorder in Taiwanese population
Carrier screening is important to people have a higher prevalence of severe recessive or X-linked genetic conditions. This study is aimed that the...
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Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
AbstractWilson disease, a rare genetic disorder resulting from mutations in the ATP7B gene disrupts copper metabolism, leading to its harmful...
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Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study
Wilson’s disease (WD) is an inherited autosomal recessive disorder of copper metabolism, and its neurological and neuropsychiatric manifestations are...
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Mutations in the ATP7B Gene in Ukrainian Patients with High Risk of Wilson’s Disease
AbstractWilson’s disease (WD) is an autosomal recessive condition caused by an impaired copper metabolism due to hereditary mutations in the ATP7B ...
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Spectrum of Mutations in the ATP7B Gene in Russian Patients with Wilson’s Disease
AbstractWilson’s disease (WD) is an autosomal recessive disease caused by an excessive accumulation of copper. The molecular genetic etiology of the...
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Adjunctive Antioxidant Therapy in Neurologic Wilson’s Disease Improves the Outcomes
Oxidative stress has been reported in Wilson’s disease with neurological manifestation (WDNM), but there is a paucity of studies on the role of...
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A probable role of copper in the comorbidity in Wilson’s and Creutzfeldt-Jakob’s Diseases: a case report
BackgroundTo the best of our knowledgedd, there is currently no case in the literature reporting the comorbidity of Wilson’s and Creutzfeldt-Jakob...
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Research progress and application of liver organoids for disease modeling and regenerative therapy
The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual incidence of liver disease...
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Altered large-scale functional brain networks in neurological Wilson’s disease
Wilson’s disease patients with neurological symptoms have motor symptoms and cognitive deficits, including frontal executive, visuospatial...
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Vitamin-Based Derivatives for the Management of Alzheimer’s Disease
Vitamins are organic compounds; they help in the regulation of many bodily functions like cell proliferation and differentiation, immunological...
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SOD1-Related Cerebellar Ataxia and Motor Neuron Disease: Cp Variant as Functional Modifier?
We describe a novel superoxide dismutase ( SOD1 ) mutation-associated clinical phenotype of cerebellar ataxia and motor neuron disease with a variant...
