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Inhibition of the Vesicular Glutamate Transporter (VGLUT) with Congo Red Analogs: New Binding Insights
AbstractThe vesicular glutamate transporter (VGLUT) facilitates the uptake of glutamate (Glu) into neuronal vesicles. VGLUT has not yet been fully...
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Inhibition of Vesicular Glutamate Transporters (VGLUTs) with Chicago Sky Blue 6B Before Focal Cerebral Ischemia Offers Neuroprotection
Brain ischemia is one of the leading causes of death and long-term disability in the world. Interruption of the blood supply to the brain is a direct...
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Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents
The analysis of organellar membrane transportersMembrane transporters presents many technical problems. In general, their activity depends on a H+...
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María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage
Chromaffin granules are secretory granules present in adrenal medulla chromaffin cells. They contain high contents of catecholamines and nucleotides...
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GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body
We previously reported the immunoreactivity for the vesicular glutamate transporter 2 (VGLUT2) in afferent nerve terminals attached to chemoreceptor...
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Pharmacological Role of Glutamate Transporters in Substance Use Disorders
Substance use disorders (SUD) represent a public health crisis worldwide. The development of effective pharmacotherapeutics to treat drug abuse and...
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Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
Vesicular glutamate transporters (VGLUTs) control quantal size of glutamatergic transmission and have been the center of numerous studies over the...
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Silencing the Output of Cerebellar Neurons Using Cell Type-Specific Genetic Deletion of Vesicular GABA and Glutamate Transporters
Neurons are distinguished from other cell types by their inherent properties such as electrical excitability and their ability to rapidly communicate...
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Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson
Incidental Lewy body disease (ILBD) is a neuropathological diagnosis of brains with Lewy bodies without clinical neuropsychiatric symptoms....
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Meta-analysis and systematic review of vesicular monoamine transporter (VMAT-2) inhibitors in schizophrenia and psychosis
RationaleDopamine antagonists induce dopamine receptor supersensitivity. This may manifest in late-appearing movement disorders (tardive dyskinesia...
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Analysis of Synaptic Glutamate Clearance as a Possible Indicator of Synaptic Health in the Degenerating Rodent Brain
Neurodegeneration may present multiple challenges when one tries to quantify the astrocytic contribution to synaptic reorganization in a diseased...
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Photooxidation of Genetically Encoded MiniSOG-Fused VGLUT2 for Identification of Glutamatergic Synapses by Transmission and 3D Electron Microscopy
Immuno-electron microscopy (EM) is fundamentally limited by problems related to hindrance of antigenicity in fixed and resin-embedded specimens and...
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Glutamate Neurotoxicity Related to Energy Failure
Glutamate is the major excitatory neurotransmitter mediating its effects via a plethora of receptors being either ionotropic or metabotropic. Each of...
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The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Epileptic seizures are frequently referred to as a brief development of a number of signs and symptoms resulting from extreme or synchronized...
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Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry
BackgroundAspects of glutamate neurotransmission implicated in normal and pathological conditions are predominantly evaluated using in vivo recording...
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Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
Remote ischaemic conditioning (RIC) becomes an attractive strategy for the endogenous stimulation of mechanisms protecting neurons against ischaemia....
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Glutamate in Migraine Neurobiology and Treatment
Migraine is a disabling chronic condition characterised by recurrent episodes of head pain accompanied by other sensory disturbances. Its...
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Glutamate in the Pathogenesis of Gliomas
Recent studies have shown that glutamate may serve important roles in the pathobiology of primary brain tumors. Glutamate is produced and secreted...
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Glutamate in the Pathogenesis of Gliomas
Recent studies have shown that glutamate may serve important roles in the pathobiology of primary brain tumors. Glutamate is produced and secreted...
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Immunohistochemical distribution of proteins involved in glutamate release in subepithelial sensory nerve endings of rat epiglottis
To elucidate the efferent functions of sensory nerve endings, the distribution of calretinin and vesicular glutamate transporter 1 (VGLUT1) in...
