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Neural Tube Formation
This chapter describes medaka development in the pre-phylotypic period, i.e., from the fertilized eggs to the embryos that have the neural tubes...
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In Vitro Tube Formation Assays in Matrigel
Vasculature development is a combination of complex processes that require precise coordination of multiple cell types, through time and space, to...
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Neurulation and Neural Tube Defects
Neurulation has been extensively studied in amphibian, avian and mammalian embryos and occurs in four stages: formation of the neural plate, sha**...
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The microsporidian polar tube: origin, structure, composition, function, and application
Microsporidia are a class of obligate intracellular parasitic unicellular eukaryotes that infect a variety of hosts, even including humans. Although...
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Ventriculo-Pial Patterning of Neural Tube
This chapter looks at the neural tube at cellular level to address the concentric patterns in neural tube. Early neural tube is a pseudostratified...
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Left–Right Patterning of Neural Tube
This chapter discusses the structural differences along the left–right axis of neural tube. Two types of left–right differences, the fixed and random...
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Simultaneous Four Supratentorial Lesions Predict Tube Dependency Due to an Impaired Anticipatory Phase of Ingestion
This study aimed to identify the neuroanatomical predictors of oropharyngeal dysphagia and tube dependency in patients with supratentorial or...
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In Situ Hybridization to Characterize Neurulation and Midbrain–Hindbrain Boundary Formation in Zebrafish
Whole-mount in situ hybridization is able to harness the inherent advantages of zebrafish as a model organism for developmental biology, particularly...
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Mechanics of Microsporidian Polar Tube Firing
As obligate intracellular parasites with reduced genomes, microsporidia must infect host cells in order to replicate and cause disease. They can...
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Evolutionary Aspects of Chamber Formation and Septation
The formed hearts of vertebrates are widely different in anatomy and performance, yet their embryonic hearts are surprisingly similar. Developmental...
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Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological...
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Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects
Neural tube defects (NTDs) are severe malformations of the central nervous system that arise from failure of neural tube closure. HECTD1 is an E3...
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Inpp5e Regulated the Cilium-Related Genes Contributing to the Neural Tube Defects Under 5-Fluorouracil Exposure
Primary cilia are crucial for neurogenesis, and cilium-related genes are involved in the closure of neural tubes. Inositol...
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The Function and Structure of the Microsporidia Polar Tube
Microsporidia are obligate intracellular pathogens that were initially identified about 160 years ago. Current phylogenetic analysis suggests that...
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Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction
It is clear that organoids are useful for studying the structure as well as the functions of organs and tissues; they are able to simulate...
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Assessment of Invadopodium Formation and Gelatin Degradation in Vitro
Some cancer cells form highly regulated structures, termed invadopodia, which mediate local, enzymatic degradation of extracellular matrix and...
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Development of Neural Circuits in Neural Tube
This chapter describes the development of fiber tracts and behavior in the medaka embryos. The fiber system develops correlated with the organization...
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Genetic Susceptibility to Neural Tube Defect (NTD) and Hyperhomocysteinemia
Increased level of homocysteine is typically caused by genetic defect in the enzyme involved in the homocysteine metabolism. Several genetic enzyme...
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Subdivisions of Neural Tube along the Rostrocaudal Axis: Neuromeric Models
This chapter discusses the transverse subdivisions, which are positioned perpendicular to the longitudinal axis of the neural tube. The medaka neural...
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Characterizing neuroinflammation and identifying prenatal diagnostic markers for neural tube defects through integrated multi-omics analysis
BackgroundNeural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural...
