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Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation
Rasagiline mesylate (RM) is a monoamine oxidase inhibitor that is commonly used to alleviate the symptoms of Parkinson’s disease. However, it suffers...
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Model-Based Evaluation of Drying Kinetics and Solvent Diffusion in Pharmaceutical Thin Film Coatings
PurposeFluid-bed coating processes make it possible to manufacture pharmaceutical products with tuneable properties. The choice of polymer type and...
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Film-Forming, Moisturizing, and Sensory Properties of a Cosmetic Formulation Containing Tara Gum and Brazilian Berry Extracts
The development of cosmetic formulations with moisturizing and film-forming properties has been very important to help keep skin physiology and...
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Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with unclear etiology and increasing prevalence. Pulmonary...
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Atorvastatin liposomes in a 3D-printed polymer film: a repurposing approach for local treatment of oral candidiasis
Oral candidiasis (OC) is an opportunistic fungal infection, common amongst the elderly and the immunocompromised. Unfortunately, the therapeutic...
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Transdermal Film Loaded with Avanafil Ultra-deformable Nanovesicles to Enhance its Percutaneous Absorption and Bioavailability
The in vitro dissolution of Avanafil (AVA) is the rate-limiting step for its bioavailability. Also, it undergoes the first-pass metabolism, and its...
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Development of clindamycin-loaded alginate/pectin/hyaluronic acid composite hydrogel film for the treatment of MRSA-infected wounds
PurposeMethicillin-resistant Staphylococcus aureus (MRSA) infection on wounds possesses a high risk in increased cases of morbidity and mortality...
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Fabrication of magnetic niosomal platform for delivery of resveratrol: potential anticancer activity against human pancreatic cancer Capan-1 cell
Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment of cancer cell. Targeted drug delivery...
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Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study
Progesterone, a female sex steroid hormone, is highly lipophilic, leading to poor oral bioavailability. This study aimed to develop a progesterone...
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Development and Optimization of Asenapine Sublingual Film Using QbD Approach
Asenapine, an atypical antipsychotic agent, has been approved for the acute and maintenance treatment of schizophrenia and manic episodes of bipolar...
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Thyme Oil–Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical...
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ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
Rivastigmine hydrogen tartrate (RHT) is an acetylcholinesterase (AChE) inhibitor used in the management of Alzheimer’s disease (AD). RHT is a BCS...
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Development of Liposomal Formulation for Controlled Delivery of Valacyclovir: an In Vitro Study
PurposeHerpes, a highly contagious viral infection caused by the herpes simplex virus, infects the face to any other body part of the skin, even the...
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Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment
BackgroundIncreased intraocular pressure is a common symptom of glaucoma. In severe circumstances, it may result in loss of eyesight. Glaucoma...
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QbD Enabled Development and Evaluation of Pazopanib Loaded Nanoliposomes for PDAC Treatment
AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the highly fatal types of cancer with high mortality/incidence. Considering the crucial...
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Development and evaluation of Resveratrol-loaded liposomes in hydrogel-based wound dressing for diabetic foot ulcer
Diabetic foot wounds (DFUs) are counted as one of the most common microvascular complications associated with poorly controlled and chronic diabetes...
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Formulation, Characterization, and Optimization of Transethosomes for Enhanced Transdermal Delivery of Methotrexate
PurposeMethotrexate (MTX) is an antineoplastic drug used in the treatment of rheumatoid arthritis (RA). Given that it is a class IV drug with low...
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Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus
PurposeThis study aimed to develop niosomes using polyoxyethylene lauryl ether (Brij-35) and poloxamer 407 surfactants for dissolution enhancement of...
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Physicochemical Characterization of Berberine-loaded Pluronic F127 Polymeric Micelles and In Vivo Evaluation of Hypoglycemic Effect
ObjectivesIn this study, a polymer micelle containing berberine (Ber) was prepared. The micelle was composed of Pluronic F127 and Ber. The...
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Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by 99mTc radiolabeling technique
Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate migraine attacks. ZT suffers various limitations; massive...
