Search
Search Results
-
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Cytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive metabolites (RMs), has been...
-
Solvent effect on the Spectra of Methylene Green and Methylene Blue
This investigation focuses on dyes that differ only in the nitro substituent. The NO 2 group leads to a strong hardening of the fluorescence at 298 K....
-
Nonsteroidal Anti-Inflammatory Drug Leads from Plant Sources
Nonsteroidal anti-inflammatory drugs are FDA-approved for their anti-inflammatory, antipyretic (fever-reducing), and analgesic (pain-relieving)...
-
Nitrogen- and Sulfur-Containing Heterocycles as Dual Anti-oxidant and Anti-cancer Agents
Cancer derives from a multi-step process in which tumor cells establish the ability to proliferate and disseminate. Other non-oncogenic pathways can...
-
Enzymes of Isoprenoid Biosynthesis and Control of Malarial Parasite Plasmodium falciparum
There is high importance for the control of parasite Plasmodium falciparum which is responsible for causing malaria. Following the classical...
-
An Overview on Antibiotic Resistance in Gram-Negative Bacteria
Antimicrobial agents have been in use since ages in various forms in curing bacterial infections. Gram-negative bacteria cause a wide range of...
-
Nitrogen- and Sulfur-Containing Heterocycles as Dual Anti-oxidant and Anti-cancer Agents
Cancer derives from a multi-step process in which tumor cells establish the ability to proliferate and disseminate. Other non-oncogenic pathways can...
-
Potential of Heterocyclic Compounds as EGFR-TK Inhibitors in Cancer Therapy
Over the last few decades, cancer has become deadliest diseases worldwide. Vascular Endothelial Growth Factor Receptor (VEGFR), Human Epidermal...
-
A Critical Appraisal of Current Status of Synthetic Antioxidant Molecules in the Treatment of Breast Cancer
Cancer is a complex disease of immortal cells that occurs due to any kind of disruption between cell division and cell death which are the two main...
-
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
Spinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal...
-
A Critical Appraisal of Current Status of Synthetic Antioxidant Molecules in the Treatment of Breast Cancer
Cancer is a complex disease of immortal cells that occurs due to any kind of disruption between cell division and cell death which are the two main...
-
8-cyanobenzothiazinone analogs with potent antitubercular activity
8-Nitrobenzothiazinones (BTZs) exemplified by macozinone are a new class of antitubercular agents with exceptionally potent activity. The aryl nitro...
-
Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
Sulfur is widely existent in natural products and synthetic organic compounds as organosulfur, which are often associated with a multitude of...
-
The Development of Highly Fluorescent Hemicyanine and Dicyanoisophorone Dyes for Applications in Dye-Sensitized Solar Cells
Ruthenium-based metal complex dyes have been employed extensively in dye-sensitized solar cells (DSSCs) as photosensitizers, but the cost and...
-
Microanalysis of Two Members of Oxicam Drugs by Quenching the Fluorescence of Newly Isolated Carbonaceous Materials From Incense Ash
For the first time ever, useful fluorescent (FL) carbonaceous materials (CMTS) were isolated from incense ash using facile procedure on two steps;...
-
Molluscicides against the snail-intermediate host of Schistosoma: a review
Schistosomiasis, a neglected tropical disease (NTD), is one of the most prevalent parasitoses in the World. Certain freshwater snail species are the...
-
Design, synthesis and identification of novel substituted isothiochromene analogs as potential antiviral and cytotoxic agents
AbstractIn this study, we present the synthesis of novel isothiochromenes, thiazolidonone, thiazinone, arylidines, triazoles, and pyrimidinone...
-
Antiplasmodial natural products: an update
BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria...
-
In Silico Strategies to Design Small Molecules to Study Beta-Amyloid Aggregation
The amyloid cascade hypothesis of Alzheimer’s disease is an intriguing and complex pathway which alludes to the accumulation of amyloid (Aβ)...
-
