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Blending, Hydrogenation , Fractionation and Interesterification Processing
The lipid industry is constantly researching and develo** techniques to improve the quality, stability, nutrition, and technological features of...
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Novel Strategy for In Vitro Validation of Babesia orientalis Heat Shock Proteins Chaperone Activity and Thermostability
BackgroundBabesia orientalis is an intra-erythrocytic protozoan parasite that causes babesiosis in water buffalo. The genome of B. orientalis has...
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A two-pronged approach against glioblastoma: drug repurposing and nanoformulation design for in situ-controlled release
Glioblastoma (GB) is one of the most lethal types of neoplasms. Its biologically aggressive nature and the presence of the blood–brain barrier (BBB)...
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Dual-Responsive Micellar Microgels Matrixed with Surface-Engineered Lipids: a New Approach for Controlled Vaginal Drug Delivery
PurposeThis study investigated surface-modified dual-responsive (bio-responsive and thermo-sensitive) micellar microgels as a novel vaginal drug...
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Measuring Protein Nuclear Transport via a Dual Reporter in iPSC-Derived Neurons
Nucleocytoplasmic transport (NCT) plays a critical role in maintaining cellular homeostasis, and its dysregulation has been shown to be implicated in...
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Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors
The adaptive immune system exhibits exquisite specificity and memory and is involved in virtually every process in the human body. Redirecting...
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Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model
Tau protein in Alzheimer’s disease (AD) and tauopathies becomes insoluble due to hyperphosphorylation, conformational alterations, and aggregation....
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Nano/microformulations for Bacteriophage Delivery
Encapsulation methodologies allow the protection of bacteriophages for overcoming critical environmental conditions. Moreover, they improve the...
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Protein Production at the 100L Scale
The Baculovirus Expression Vector System (BEVS) has revolutionized the field of recombinant protein expression by enabling efficient and high yield...
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Applications of Block Copolymers as Stimuli-Responsive Copolymers
Stimuli-responsive polymers (smart polymers) are macromolecules that change their physicochemical properties in response to specific triggers from...
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Spoilage potential of psychrotrophic bacteria isolated from raw milk and the thermo-stability of their enzymes
The storage and transportation of raw milk at low temperatures promote the growth of psychrotrophic bacteria and the production of thermo-stable...
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High-Throughput Screening to Identify Modulators of Sarcospan
High-throughput screening enables the discovery of disease-modifying small molecules. Here, we describe the development of a scalable, cell-based...
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Luminescence-Based Techniques for KRAS Thermal Stability Monitoring
Various biochemical methods have been introduced to detect and characterize KRAS activity and interactions, from which the vast majority is based on...
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Ribosome Profiling of Plants
Translation is a key step in control of gene expression, yet most analyses of global responses to a stimulus focus on transcription and the...
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A Revised Diagnostic Quantitative RT-PCR for the Detection of Nipah Virus Infection
From its discovery in Malaysia in the late 1990s, the spillover of the Nipah virus from its pteropid reservoir into the human population has resulted...
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Role of Block Co-Polymers in Drug Delivery
Block co-polymers are extensively used in drug delivery applications, including the preparation of advanced co-polymeric nanocarrier systems and...
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Gelatin In Situ Zymography to Study Gelatinase Activity in Colon Cancer Cells Treated with Platelet Microparticles (PMPs)
The platelet-derived microparticles (PMPs) have been connected with tumor progression and metastatic dissemination. PMPs infiltrate solid tumors and...
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In Vivo Viral Gene Delivery to Manipulate Functional Properties of AMPA Receptors in Oligodendrocyte Lineage Cells
Delivery or deletion of genes of interest in the nervous system of animals in vivo is a complex and difficult task. While genetic manipulations can...
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Gellan Gum-Based Films
Gellan gum is an anionic extracellular biodegradable microbial-derived polymer which finds application in food and biomedical and pharmaceutical...
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A Three-Dimensional Organoid Culture System to Model Invasive Patterns of Patient-Derived Glioma Stem Cells
Glioblastoma multiformes (GBMs) are recurring brain tumors containing self-renewing glioma stem cells (GSCs), which contribute to tumor initiation...