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The Influence of AA29504 on GABAA Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity
The unique pharmacological properties of δ-containing γ-aminobutyric acid type A receptors (δ-GABA A Rs) make them an attractive target for selective...
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GABA tone regulation and its cognitive functions in the brain
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at GABAergic synapses, mediating fast-acting phasic inhibition. Emerging...
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Effects of Back-Support Exoskeleton Use on Lower Limb Joint Kinematics and Kinetics During Level Walking
We assessed the effects of using a passive back-support exoskeleton (BSE) on lower limb joint kinematics and kinetics during level walking. Twenty...
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Alcohol and the Cerebellum
Alcohol (EtOH) is a socially accepted and widely used psychoactive compound, derived from the fermentation/distillation of various plant sugars....
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The Role of Extrasynaptic GABA Receptors in Postpartum Depression
Postpartum depression is a serious disease with a high incidence and severe impact on pregnant women and infants, but its mechanism remains unclear....
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GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks
Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state...
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Social experience and sex-dependent regulation of aggression in the lateral septum by extrasynaptic δGABAA receptors
RationaleUnderstanding the neurobiological mechanisms mediating dominance and competitive aggression is essential to understanding the development...
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Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome
BackgroundRett syndrome (RTT) is a neurodevelopmental disorder caused mostly by disruptions in the MECP2 gene. MECP2 -null mice show imbalances in...
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Pharmacology of GABA and Its Receptors
GABA is an important neurotransmitter in vertebrates where it acts at synapses of the CNS; in nematodes GABA acts primarily at neuromuscular...
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Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature
We review advances in understanding Purkinje cell (PC) complex spike (CS) physiology that suggest increased CS synchrony underlies syndromic...
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Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome
Angelman syndrome (AS) is a rare (~1:15,000) neurodevelopmental disorder characterized by severe developmental delay and intellectual disability,...
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Neurotransmitters and Neurotransmission
Normal functioning of the human brain requires parallel and sequential innumerous neurotransmission processes that are fine-tuned by countless...
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Effects of GABAA receptors in nucleus cuneiformis on the cannabinoid antinociception using the formalin test
RationaleNucleus cuneiformis (NC), a reticular nucleus of the midbrain, is a part of the descending pain modulatory system and therefore has an...
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Two distinct mechanisms for experience-dependent homeostasis
Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing...
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Ca2+ Signaling in Oligodendrocyte Development
Calcium signaling has essential roles in the development of the nervous system, from neural induction to the proliferation, migration, and...
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The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder
In the brain, fast inhibitory neurotransmission is mediated primarily by the ionotropic subtype of the gamma-aminobutyric acid (GABA) receptor...