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Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer’s Disease: Where is the Way?

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References

  1. Schweitzer JS, Song B, Herrington TM, Park TY, Lee N, Ko S. Personalized iPSC-derived dopamine progenitor cells for Parkinson’s disease. N Engl J Med 2020, 382: 1926–1932.

    Article  CAS  Google Scholar 

  2. Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, Rábano A, Cafini F, Pallas-Bazarra N, et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat Med 2019, 25: 554–560.

    Article  Google Scholar 

  3. Tobin MK, Musaraca K, Disouky A, Shetti A, Bheri A, Honer WG, et al. Human hippocampal neurogenesis persists in aged adults and Alzheimer’s disease patients. Cell Stem Cell 2019, 24: 974–982.

    Article  CAS  Google Scholar 

  4. Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, et al. Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 2018, 22: 589–599.

    Article  CAS  Google Scholar 

  5. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science 2018, 361: n8821.

    Article  Google Scholar 

  6. Miller SM, Sahay A. Functions of adult-born neurons in hippocampal memory interference and indexing. Nat Neurosci 2019, 22: 1565–1575.

    Article  CAS  Google Scholar 

  7. Zheng J, Li HL, Tian N, Liu F, Wang L, Yin Y, et al. Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell 2020, 26: 331–345.

    Article  CAS  Google Scholar 

  8. Liu F, Tian N, Zhang HQ, Li SH, Zhou QZ, Yang Y, et al. GSK-3beta activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. Theranostics 2020, 10: 9674–9685.

    Article  CAS  Google Scholar 

  9. Crowther AJ, Song J. Activity-dependent signaling mechanisms regulating adult hippocampal neural stem cells and their progeny. Neurosci Bull 2014, 30: 542–556.

    Article  CAS  Google Scholar 

  10. Hunsberger JG, Rao M, Kurtzberg J, Bulte J, Atala A, LaFerla FM, et al. Accelerating stem cell trials for Alzheimer’s disease. Lancet Neurol 2016, 15: 219–230.

    Article  Google Scholar 

  11. Duncan T, Valenzuela M. Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res Ther 2017, 8: 111.

    Article  Google Scholar 

  12. Fan X, Sun D, Tang X, Cai Y, Yin ZQ, Xu H. Stem-cell challenges in the treatment of Alzheimer’s disease: a long way from bench to bedside. Med Res Rev 2014, 34: 957–978.

    Article  CAS  Google Scholar 

  13. Li X, Zhu H, Sun X, Zuo F, Lei J, Wang Z, et al. Human Neural Stem cell transplantation rescues cognitive defects in app/ps1 model of Alzheimer’s disease by enhancing neuronal connectivity and metabolic activity. Front Aging Neurosci 2016, 8: 282.

    PubMed  PubMed Central  Google Scholar 

  14. Yin JC, Zhang L, Ma NX, Wang Y, Lee G, Hou XY, et al. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways. Stem Cell Reports 2019, 12: 488–501.

    Article  CAS  Google Scholar 

  15. Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G. In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s disease model. Cell Stem Cell 2014, 14: 188–202.

    Article  CAS  Google Scholar 

  16. Mattugini N, Bocchi R, Scheuss V, Russo GL, Torper O, Lao CL, et al. Inducing different neuronal subtypes from astrocytes in the injured mouse cerebral cortex. Neuron 2019, 103: 1086–1095.

    Article  CAS  Google Scholar 

  17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 2020, 582: 550–556.

    Article  CAS  Google Scholar 

  18. Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, et al. Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice. Cell 2020, 181: 590–603.

    Article  CAS  Google Scholar 

  19. Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early Alzheimer’s disease. Neuron 2017, 93: 533–541.

    Article  CAS  Google Scholar 

  20. Wu Z, Parry M, Hou XY, Liu MH, Wang H, Cain R,et al. Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease. Nat Commun 2020, 11: 1105.

    Article  CAS  Google Scholar 

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Acknowledgements

This insight article was supported by the National Natural Science Foundation of China (81901107) and the China Postdoctoral Science Foundation (2018M632872).

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Authors and Affiliations

  1. Department of Pharmacology, Key Laboratory of Basic Pharmacology of Ministry of Education, Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University, Zunyi, 563000, China

    Jie Zheng

  2. Digestive Disease Institute of Guizhou Province, Clinical Medical Research Center of Digestive Diseases of Guizhou Province, Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China

    Yawen Li

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  1. Jie Zheng
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  2. Yawen Li
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Correspondence to Jie Zheng.

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Zheng, J., Li, Y. Compensation for Neurodegeneration by Hippocampal Neurogenesis in Alzheimer’s Disease: Where is the Way?. Neurosci. Bull. 37, 885–888 (2021). https://doi.org/10.1007/s12264-021-00660-5

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  • DOI: https://doi.org/10.1007/s12264-021-00660-5

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