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Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta
As a risk factor for Alzheimer’s disease (AD), studies have demonstrated that long-term high-fat diet (HFD) could accelerate the deposition of...
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Upregulation of SNTB1 correlates with poor prognosis and promotes cell growth by negative regulating PKN2 in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the most highly malignant tumors and has a complicated pathogenesis. A preliminary study identified...
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Expression of Dystrophin Dp71 Splice Variants Is Temporally Regulated During Rodent Brain Development
Dystrophin Dp71 is the major product of the Duchenne muscular dystrophy ( DMD ) gene in the brain, and its loss in DMD patients and mouse models leads...
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Different waves of postglacial recolonisation and genomic structure of bank vole populations in NE Poland
Previous studies indicated that in some species phylogeographic patterns obtained in the analysis of nuclear and mitochondrial DNA (mtDNA) markers...
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Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes
The scaffold protein alpha-syntrophin (SNTA) is a component of the dystrophin glycoprotein complex and has been comprehensively studied in skeletal...
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Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy
Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to primary abnormalities in one of the largest genes in the human...
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Clinical and Genetic Characteristics of Congenital Long QT Syndrome
AbstractLong QT syndrome is a rare ion channel cardiac disorder, the main manifestations of which are prolongation of the QT interval on the ECG and...
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Enolase
Glycolysis is an ancient metabolic, oxygen-dependent, mostly cytosolic pathway that brings about conversion of glucose to pyruvate with the release...
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The role of astrocytes in the glymphatic network: a narrative review
To date, treatment of Central Nervous System (CNS) pathology has largely focused on neuronal structure and function. Yet, revived attention towards...
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Molecular Pathways and Animal Models of Arrhythmias
Arrhythmias account for over 300,000 annual deaths in the United States, and approximately half of all deaths are associated with heart disease....
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Molecular Pathways and Animal Models of Cardiomyopathies
Cardiomyopathies are a heterogeneous group of disorders of the heart muscle that ultimately result in congestive heart failure. Rapid progress in...
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Seizures
A brief introduction to the pathology of epilepsy is presented. Seizure-prone areas of the brain are always accompanied by reactive gliosis. These...
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Enolase
Glycolysis is an ancient metabolic, oxygen-dependent, mostly cytosolic pathway that brings about conversion of glucose to pyruvate with the release...
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Aberrant epigenetic and transcriptional events associated with breast cancer risk
BackgroundGenome-wide association studies have identified several breast cancer susceptibility loci. However, biomarkers for risk assessment are...
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Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain
Evidence suggests that extracellular matrix molecules of perivascular basal laminae help orchestrate the molecular assemblies at the gliovascular...
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Muscular Dystrophy: Underlying Cellular and Molecular Mechanisms and Various Nanotherapeutic Approaches for Muscular Dystrophy
Muscular dystrophy (MD) corresponds to a cluster of approximately 30–40 genetically controlled diseases, which exhibit inheritance patterns that are...
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Nitrosative stress in Parkinson’s disease
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal...
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Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the...
