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Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
As a potential vectored vaccine, Newcastle disease virus (NDV) has been subject to various studies for vaccine development, while relatively little...
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Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
BackgroundInfluenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health. Vaccination of pigs is the most...
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African Swine Fever Virus
African swine fever virus introduction to naïve swine population leads to high mortality and losses among susceptible animals. ASF epidemic in Russia...
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A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
BackgroundInfluenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes...
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Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model
BackgroundEstablishment of transplantable tumors in clinically relevant large animals allows translational studies of novel cancer therapeutics.
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An Updated Review on Influenza Viruses
Influenza virus is a highly contagious respiratory virus also known as seasonal flu. This virus belongs to the Orthomyxoviridae family and its genome...
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mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop...
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Roles of Glycans and Non-glycans on the Epithelium and in the Immune System in H1–H18 Influenza A Virus Infections
The large variation of influenza A viruses (IAVs) in various susceptible hosts and their rapid evolution, which allows host/tissue switching, host...
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Influenza from a One Health Perspective: Infection by a Highly Versatile Virus
Influenza A viruses (IAVs) are among the most versatile viruses, in terms of host range, pathogenesis, route of transmission, transmissibility...
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The Cellular and Epigenetic Aspects of Trained Immunity and Prospects for Creation of Universal Vaccines on the Eve of More Frequent Pandemics
The inevitability of pandemics outbreaks creates an urgent requirement for emergency action to develop effective technologies to reduce harm to the...
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Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens
Xenotransplantation of pig organs into people may help alleviate the critical shortage of donors which faces organ transplantation. Unfortunately,...
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Regeneration of Urologic Tissues and Organs
Patients suffering from a variety of urologic diseases may be treated with transplanted tissues and organs. However, there is a shortage of donor...
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Development of conserved multi-epitopes based hybrid vaccine against SARS-CoV-2 variants: an immunoinformatic approach
The world has faced unprecedented disruptions like global quarantine and the COVID-19 pandemic due to SARS-CoV-2. To combat these unsettling...
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Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance
Macrophages are one of the first innate immune cells to reach the site of infection or injury. Diverse functions from the uptake of pathogen or...
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Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines
Extracellular vesicles (EVs) are tiny, lipid membrane-bound structures that are released by most cells. They play a vital role in facilitating...
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Influenza from a One Health Perspective: Infection by a Highly Versatile Virus
Influenza A viruses (IAVs) are among the most versatile viruses, in terms of host range, pathogenesis, route of transmission, transmissibility...
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Comprehensive Risk Assessment of Infection Induced by SARS-CoV-2
The pandemic COVID-19 (coronavirus disease 2019) is caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which devastated the...
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Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)
Occasional zoonotic viral attacks on immunologically naive populations result in massive death tolls that are capable of threatening human survival....
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Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases
Mesenchymal stem cells (MSCs) play diverse roles ranging from regeneration and wound healing to immune signaling. Recent investigations have...
