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Biomedicine

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Showing 1-19 of 19 results

  1. A Pyrene-Tetrazole Fused Fluorescent Probe for Effective Real Time Detection Towards Aluminium Ion

    We constructed a novel-binding site for metal ion detection using a fused tetrazole ring conjugated with aminopyrene ( R ). The designed structure of...

    Ramalingam Manivannan, Young-A Son in Journal of Fluorescence
    Article 06 June 2022

  2. Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s

    Many nitrosamines are recognized as mutagens and potent rodent carcinogens. Over the past few years, nitrosamine impurities have been detected in...

    **lin Li, **aobo He, ... Nan Mei in Archives of Toxicology
    Article 26 July 2022

  3. DMPK Lead Optimization

    The optimizationOptimizations and discovery of small molecule drugs has evolved in the past decades. Since the mid-1990s, in vitro ADME assays have...
    S. Cyrus Khojasteh, Harvey Wong, ... Cornelis E.C.A. Hop in Discovery DMPK Quick Guide
    Chapter 2022

  4. Physico-Chemical Mechanisms

    Connecting with the enzyme, the substrate (succinate, NADH, etc.) is largely purified from the water coat and is located in the space of the desired...
    Nikolai Vekshin in Biophysics of Mitochondria
    Chapter 2019

  5. Tag-Creation Approaches for Highly Efficient Profiling of Interacting Proteins and Domains

    Diazirine-based photoaffinity labeling is recognized as one of the most reliable methods for identification of biomolecular interactions because of...
    Takenori Tomohiro in Photoaffinity Labeling for Structural Probing Within Protein
    Chapter 2017

  6. Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA Repair Studies

    DNA is continuously exposed to various damaging conditions (oxidizing agents, UV, ionizing radiations, or endogenous species) that produce strand...
    Rémy Lartia in Modified Nucleic Acids in Biology and Medicine
    Chapter 2016

  7. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

    The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease researchers as a way of resolving the lack of...

    Iryna Benilova, Eric Karran, Bart De Strooper in Nature Neuroscience
    Article 29 January 2012

  8. Chemistry of Locked Nucleic Acids (LNA)

    Preparation of LNA nucleosides requires a number of synthetic steps but very efficient procedures have been developed, as have protocols for...
    Jesper Wengel, Michael Petersen, ... Troels Koch in Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules
    Chapter 2006

  9. Cymbopogon citratus

    This densely tufted perennial of the GRAMINEAE family has leaf blades tapered to both ends up to 1 meter long and 5 to 10 mm wide. The flowering...
    Ivan A. Ross in Medicinal Plants of the World
    Chapter 2003

  18. Deutsche Pharmakologische Gesellschaft

    Problem 1) Maximum unknown, baseline increased, drug effects overadditively enhanced: the examination of dose response curves of...
    in Deutsche Pharmakologische Gesellschaft
    Chapter 1981

  19. Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins

    The determination of antigenic structures of proteins presents a major challenge, which is primarily chemical in nature. The chemical strategy set...
    M. Z. Atassi in Immunochemistry of Proteins
    Chapter 1977
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