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Prognosis prediction based on methionine metabolism genes signature in gliomas
BackgroundGlioma cells have increased intake and metabolism of methionine, which can be monitored with 11 C-L-methionine. However, a short half-life...
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Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction
BackgroundA major obstacle to the development of personalized therapies for gastric cancer (GC) is the prevalent heterogeneity at the intra-tumor,...
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Prediction of prognosis in glioblastoma with radiomics features extracted by synthetic MRI images using cycle-consistent GAN
To propose a style transfer model for multi-contrast magnetic resonance imaging (MRI) images with a cycle-consistent generative adversarial network...
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Novel risk model based on angiogenesis-related lncRNAs for prognosis prediction of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death due to early metastasis or recurrence. Tumor angiogenesis plays an essential...
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Signature Construction and Disulfidptosis-Related Molecular Cluster Identification for Better Prediction of Prognosis in Glioma
Disulfidptosis is a newly discovered form of regulatory cell death. However, the identification of disulfidptosis-related molecular subtypes and...
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Comprehensive assessment of the genetic characteristics of small for gestational age newborns in NICU: from diagnosis of genetic disorders to prediction of prognosis
BackgroundIn China, ~1,072,100 small for gestational age (SGA) births occur annually. These SGA newborns are a high-risk population of developmental...
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Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population
BackgroundMost patients with intrahepatic cholangiocarcinoma (ICC) have developed distant metastasis at the time of diagnosis, while there is rear...
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Development and validation of cuproptosis-related lncRNA signatures for prognosis prediction in colorectal cancer
BackgroundCuproptosis, a novel form of programmed cell death, plays an essential role in various cancers. However, studies of the function of...
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A hypoxia–glycolysis–lactate-related gene signature for prognosis prediction in hepatocellular carcinoma
BackgroundLiver cancer ranks sixth in incidence and third in mortality globally and hepatocellular carcinoma (HCC) accounts for 90% of it. Hypoxia,...
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Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients
BackgroundThe lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with...
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Distinct tumor microenvironment landscapes of rectal cancer for prognosis and prediction of immunotherapy response
PurposeTumor microenvironment (TME) affects the progression of rectal cancer (RC), and the clinical relevance of its immune elements was widely...
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Accurate prediction of stomach adenocarcinomas of poorest and best prognosis with a combination of gene expression and clinical signatures
The genetic heterogeneity hampers the identification of biomarkers for Stomach adenocarcinoma (STAD). Here, we proposed a new pipeline to screen the...
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Utilizing a novel model of PANoptosis-related genes for enhanced prognosis and immune status prediction in kidney renal clear cell carcinoma
Kidney renal clear cell carcinoma (KIRC) is the most common histopathologic type of renal cell carcinoma. PANoptosis, a cell death pathway that...
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Identification of mutational signature for lung adenocarcinoma prognosis and immunotherapy prediction
AbstractThere is no robust genomic signature to predict the prognosis of patients with early-stage lung adenocarcinoma (LUAD). It was known that...
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Potential non-invasive biomarkers in tumor immune checkpoint inhibitor therapy: response and prognosis prediction
Immune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for diverse malignancies. Yet, only 15–60% of patients respond...
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Development and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction
BackgroundThe majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic...
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Signature construction and molecular subtype identification based on immune-related genes for better prediction of prognosis in hepatocellular carcinoma
ObjectiveHepatocellular carcinoma (HCC) immunotherapy is a focus of current research. We established a model that can effectively predict the...
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A novel NHEJ gene signature based model for risk stratification and prognosis prediction in hepatocellular carcinoma
BackgroundNon-homologous DNA end joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in human. However, the relationship...
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A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma
BackgroundThe prognosis of wild-type BRAF cutaneous melanoma (WT Bf-CM) patients remains poor due to the lack of therapeutic options. However, few...
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Lipid Metabolism-Related Gene Markers Used for Prediction Prognosis, Immune Microenvironment, and Tumor Stage of Pancreatic Cancer
Recently, more and more evidence shows that lipid metabolism disorder has been observed in tumor, which impacts tumor cell proliferation, survival,...
