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Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
BackgroundProtein arginine methyltransferase 5 (Prmt5) is the main type II methyltransferase, catalyzes protein arginine residue symmetric...
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Exosomal circRNA RHOT1 promotes breast cancer progression by targeting miR-204-5p/ PRMT5 axis
BackgroundCircular RNA RHOT1 (circRHOT1) plays crucial roles in tumorigenesis by competing with microRNAs. It is largely abundant in tumor...
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Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation
Long-term treatment with adriamycin (ADR) is associated with higher incidences of cumulative cardiotoxicity manifest as heart failure. ADR-induced...
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PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours
The protein arginine methyltransferase 5 (PRMT5), which is highly expressed in tumour tissues, plays a crucial role in cancer development. However,...
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Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer
BackgroundProtein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are...
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Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer
BackgroundInhibitors of
P oly (A DP-R ibose)P olymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising...
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Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer
BackgroundProtein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation....
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PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining
DNA double-strand breaks (DSBs) are widely accepted to be the most deleterious form of DNA lesions that pose a severe threat to genome integrity. Two...
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Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations
Constant challenges for the treatment of mantle cell lymphoma (MCL) remain to be recurrent relapses and therapy resistance, especially in patients...
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The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression
BackgroundDownregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal...
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The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression
BackgroundProstate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it is...
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PRMT5: a putative oncogene and therapeutic target in prostate cancer
Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago. The first decade focused on the biochemical characterization of PRMT5 as...
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The role of protein arginine methylation 5 in DNA damage repair and cancer therapy
Protein arginine methylation, a post-translational modification (PTM), is fundamental in regulating protein function and stability. Among the nine...
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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most...
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Protein arginine methyltransferase 5: a potential cancer therapeutic target
BackgroundPRMT5 is a type II protein arginine methyltransferase that methylates histone or non-histone proteins. Arginine methylation by PRMT5 has...
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ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases....
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The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells
BackgroundCFLAR L , also known as c-FLIP L , is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous...
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Protein arginine methylation: from enigmatic functions to therapeutic targeting
Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets. PRMTs regulate transcription, splicing, RNA biology, the...
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Epigenetic Alterations as an Adaptive Response to Chemotherapy
The growing field of cancer research has revealed the complex interaction between epigenetic modifications and the development of drug resistance in...
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Critical Roles of Protein Arginine Methylation in the Central Nervous System
A remarkable post-transitional modification of both histones and non-histone proteins is arginine methylation. Methylation of arginine residues is...
