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Presynaptic Cytomatrix Proteins
The Cytomatrix Assembled at the active Zone (CAZ) of a presynaptic terminal displays electron-dense appearance and defines the center of the synaptic...
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Presynaptic Dysfunction in Parkinson’s Disease
Parkinson’s disease (PD) is followed by neurodegeneration that causes impairment of body movement, nervous system abnormalities, and sleep disorders....
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Regulation of Presynaptic Calcium Channels
Voltage-gated calcium channels (VGCCs), especially Cav2.1 and Cav2.2, are the major mediators of Ca2+ influx at the presynaptic membrane in response...
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The Architecture of the Presynaptic Release Site
The architecture of the presynaptic release site is exquisitely designed to facilitate and regulate synaptic vesicle exocytosis. With the...
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P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission
Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence has been reported about the role of this nucleotide and...
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Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules
The synapse is a highly specialized asymmetric structure that transmits and stores information in the brain. The size of pre- and postsynaptic...
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Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying...
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Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
Synaptic activity imposes large energy demands that are met by local adenosine triphosphate (ATP) synthesis through glycolysis and mitochondrial...
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Local modulation by presynaptic receptors controls neuronal communication and behaviour
Central nervous system neurons communicate via fast synaptic transmission mediated by ligand-gated ion channel (LGIC) receptors and slower...
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Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in...
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Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion
Neurotransmitter release is a spatially and temporally tightly regulated process, which requires assembly and disassembly of SNARE complexes to...
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Imaging Microtubule Network in Rodent Giant Glutamatergic Presynaptic Terminals
Increasing interest and evidence have pointed to the critical role of cytoskeleton elements such as microtubules or actin filaments in the regulation...
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The Presynaptic α2δ Protein Family and Their Therapeutic Potential
α2δ proteins are well-established modulators of membrane expression and biophysical properties of voltage-gated calcium channels. Moreover, they are...
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Selectively RNA interaction by a hnRNPA/B-like protein at presynaptic terminal of squid neuron
In previous works, we identified a RNA-binding protein in presynaptic terminal of squid neurons, which is likely involved in local mRNA processing....
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Neddylation is required for presynaptic clustering of mGlu7 and maturation of presynaptic terminals
Neddylation is a posttranslational modification in which NEDD8 is conjugated to a target substrate by cellular processes similar to those involved in...
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Measuring Presynaptic Release Probability
Measuring the probability of neurotransmitter releaseNeurotransmitter release (Pr) at chemical synaptic connections can provide valuable insights as...
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BoutonNet: an automatic method to detect anterogradely labeled presynaptic boutons in brain tissue sections
Neurons emit axons, which form synapses, the fundamental unit of the nervous system. Neuroscientists use genetic anterograde tracing methods to label...
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GABAB receptors constrain glutamate presynaptic release and postsynaptic actions in substantia gelatinosa of rat spinal cord
The substantia gelatinosa (SG, lamina II of spinal cord gray matter) is pivotal for modulating nociceptive information from the peripheral to the...
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The Reorganization of the Actin Matrix as a Factor of Presynaptic Plasticity
Abstract —We review modern concepts on the mechanisms of actin involvement in coordination of presynaptic functions. In addition to the role of the...