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Designing High Binding Affinity Peptides for MHC Class I Using MAM: An In Silico Approach
The availability of extensive MHC-peptide binding data has boosted machine learning-based approaches for predicting binding affinity and identifying...
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DeepHLApan: A Deep Learning Approach for the Prediction of Peptide-HLA Binding and Immunogenicity
Neoantigens are crucial in distinguishing cancer cells from normal ones and play a significant role in cancer immunotherapy. The field of...
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Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding
Two aims of oxytocin receptor (OTR)-targeted drug discovery are development of selective OTR-binding PET tracers and development of brain-permeable...
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TAT-W61 peptide attenuates neuronal injury through blocking the binding of S100b to the V-domain of Rage during ischemic stroke
AbstractIschemic stroke is a devastative nervous system disease associated with high mortality and morbidity rates. Unfortunately, no clinically...
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Rapid Identification of MHCII-Binding Peptides Through Microsphere-Assisted Peptide Screening (MAPS)
CD4+ T cells play a vital role in the immune response, and their function requires T cell receptor (TCR) recognition of peptide epitopes presented in...
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Map** the Binding Sites of MMPs on Types II and III Collagens Using Triple-Helical Peptide Toolkits
Libraries of triple-helical collagen-like peptides (Collagen Toolkits) have helped to define collagens II and III binding specificities of numerous...
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Protein Purification by Affinity Chromatography
Affinity chromatography involves targeted purification of biological macromolecules from a crude mixture on the basis of highly specific interaction...
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Peptide aptamer-based time-resolved fluoroimmunoassay for CHIKV diagnosis
BackgroundChikungunya virus (CHIKV) and Dengue virus (DENV) have similar clinical symptoms, which often induce misdiagnoses. Therefore, an antigen...
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Discovery of HLA-E-Presented Epitopes: MHC-E/Peptide Binding and T-Cell Recognition
Understanding the interactions involved during the immunological synapse between peptide, HLA-E molecules, and TCR is crucial to effectively target...
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Detection of Granzyme B-associated Binding Targets in Peripheral Blood Samples of Hosts in Sickness and in Health Using a Granzyme B-like Peptide Fluorescent Conjugate (GP1R)
Granzyme B, mostly expressed by cytotoxic T lymphocytes in the fight against cancer and infection, is known to induce cell death based on its active...
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Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent
Pyrrolidine-based cationic peptides showing high stability to enzyme degradation and strong binding affinity towards DNA are widely investigated as...
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BioID Analysis of Actin-Binding Proteins
Proteins often exist and function as part of higher-order complexes or networks. A challenge is to identify the universe of proximal and interacting...
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Neuropeptide Binding Autoantibodies Regulating Neuroendocrine Communications
Immunoglobulin (Ig) molecules or antibodies binding neuropeptides or peptide hormones that regulate motivated behavior, stress, and emotion, such as...
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A Brief Insight into Peptide and Non-Peptide Drugs of Fungal Origin
Microorganisms are valuable resources for obtaining bioactive compounds, which have proven to be very useful in various domains, e.g., agriculture,...
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Inactivation of cell-free HIV-1 by designing potent peptides based on mutations in the CD4 binding site
Human immunodeficiency virus type 1 (HIV-1) is a major global health problem, with over 38 million people infected worldwide. Current anti-HIV-1...
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IConMHC: a deep learning convolutional neural network model to predict peptide and MHC-I binding affinity
Tumor-specific neoantigens are mutated self-peptides presented by tumor cell major histocompatibility complex (MHC) molecules and are necessary to...
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Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
Develo** therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina HiSeq platform...
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Evaluation of homodimer 99mTc-HYNIC-E(SSSLTVPWY)2 peptide on HER2-over expressed breast cancer cells
The evidence resulting from a previous preclinical study of dimer LTVPWY peptide ( 99m Tc-DLY) has proved the capability of the tracer to recognize...
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Computational Methods for Peptide Macrocycle Drug Design
Peptide macrocycles represent a promising class of therapeutics, albeit one that is under-represented amongst existing drugs. One disadvantage of...
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The optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation
The C -terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells...
