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Measuring Neuronal Network Activity Using Human Induced Neuronal Cells
Synchronous firing of neurons, often referred to as “network activity” or “network bursting,” is an indication of a mature and synaptically connected...
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Neuronal Histone Methyltransferase EZH2 Regulates Neuronal Morphogenesis, Synaptic Plasticity, and Cognitive Behavior in Mice
The histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)-mediated trimethylation of histone H3 lysine 27...
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Plasticity of Neuronal Interactions
In Chap. 4, Bill Kristan, Jr. describes his joint work with his PhD advisor, George Gerstein, demonstrating plasticity of neuronal interactions in...
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Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opportunities and Limitations
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughtout the body. Classically, nAChRs were considered to mediate fast synaptic...
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Dynamics of Neuronal Interactions
In this chapter, Ad Aertsen describes his joint work with his postdoc advisor and, later on his colleague, George Gerstein, on designing and applying...
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Unleashing Axonal Regeneration Capacities: Neuronal and Non-neuronal Changes After Injuries to Dorsal Root Ganglion Neuron Central and Peripheral Axonal Branches
Peripheral nerves obtain remarkable regenerative capacity while central nerves can hardly regenerate following nerve injury. Sensory neurons in the...
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Synaptic Tagging and Metaplasticity as Mediators of Neuronal Consciousness
Forming memories for highly arousing, novel, or salient events engages synaptic mechanisms that allow the association of temporally remote events and...
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Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Microglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase...
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Neuronal Fractal Dynamics
Synapse formation is a unique biological phenomenon. The molecular biological perspective of this phenomenon is different from the fractal...
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All-Optical Methods to Study Neuronal Function
This open access volume provides an overview of the latest methods used to study neuronal function with all-optical experimental approaches, where...
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Age-related dysregulation of homeostatic control in neuronal microcircuits
Neuronal homeostasis prevents hyperactivity and hypoactivity. Age-related hyperactivity suggests homeostasis may be dysregulated in later life....
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Mechanisms of Neuronal Apoptosis and Excitotoxicity
Neurons are postmitotic cells that may remain functional for years and cannot be replaced easily, so irreversible neuronal damage could result in...
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Overnight neuronal plasticity and adaptation to emotional distress
Expressions such as ‘sleep on it’ refer to the resolution of distressing experiences across a night of sound sleep. Sleep is an active state during...
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Involvement of histone methylation in the regulation of neuronal death
Neuronal death occurs in various physiological and pathological processes, and apoptosis, necrosis, and ferroptosis are three major forms of neuronal...
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Microglial ferroptotic stress causes non-cell autonomous neuronal death
BackgroundFerroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron....
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Excitotoxic Storms of Ischemic Stroke: A Non-neuronal Perspective
Numerous neurological disorders share a fatal pathologic process known as glutamate excitotoxicity. Among which, ischemic stroke is the major cause...
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Reconstitution of Neuronal Motor Traffic on Septin-Associated Microtubules
Reconstitution of intracellular transport in cell-free in vitro assays enables the understanding and dissection of the molecular mechanisms that...
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Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However,...
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Ethics and regulation of neuronal optogenetics in the European Union
Neuronal optogenetics is a technique to control the activity of neurons with light. This is achieved by artificial expression of light-sensitive ion...
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A biophysical perspective on the resilience of neuronal excitability across timescales
Neuronal membrane excitability must be resilient to perturbations that can take place over timescales from milliseconds to months (or even years in...
