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Glycyrrhizin and boswellic acids, the golden nutraceuticals: multitargeting for treatment of mild–moderate COVID-19 and prevention of post-COVID cognitive impairment
Breakthrough infections have been reported in fully vaccinated persons. Furthermore, rebound symptoms have been reported following the new FDA...
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Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging
The most challenging task in targeting the brain is trespassing the blood–brain barrier (BBB) which restricts the movement of about 98% small...
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Synergistic Herb-Drug Interactions Against Bacteria
Pharmacodynamic phytochemical/extract-antibiotic interactions can modify the efficacy of the antibiotic by reversal of antibiotic resistance...
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Synergistic Herb-Drug Interactions Against Viral Diseases
Emerging or reemerging viruses are of serious concern as they are associated with higher degree of mortality and deleterious impact on human life....
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Synergistic Herb Interactions with Anticancer Drugs
Cancer is emerging globally as one of the most important public health concerns. Lung, colorectal, prostate, stomach, and breast cancers account for...
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Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antileishmanial Drugs
Mortalities associated with leishmaniasis are skyrocketing at an alarming rate. Lack of vaccine for leishmaniasis treatment is making the fight...
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Polypharmacology and Natural Products
Natural products (NPs) play an important role in drug discovery. No less than 50% of the Food and Drug Administration (FDA)-approved drugs were NPs...
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Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons in the spinal cord....
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Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro
BackgroundGlioblastoma represents a brain tumor with a notoriously poor prognosis. First-line therapy may include adjunctive Tumor Treating Fields...
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Synergistic Herb-Drug Interactions Against Tuberculosis
Tuberculosis is an age-old disease that still torments the health system despite decades of vaccination and chemotherapeutic interventions. The...
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Memantine-Based Derivatives: Synthesis and Their Biological Evaluation
Alzheimer’s disease (AD) is a chronic neurological disorder characterized by memory loss and cognitive decline. It is a multifactorial disease, and a...
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Strategies of Polypharmacology
In Chap. 1 , we have learned that the modern pharmacological therapy of human disease and new drug discovery are...
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Medicinal Polypharmacology in the Clinic – Translating the Polypharmacolome into Therapeutic Benefit
Drugs with multiple targets, often annotated as ‘unselective’, ‘promiscuous’, ‘multitarget’, or ‘polypharmacological’, are widely considered in both...
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Polypharmacology in Clinical Applications: Respiratory Polypharmacology
The respiratory system is an open system that allows us to breathe, bring oxygen into our bodies (called inspiration or inhalation), and send carbon...
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Conclusion
Combination therapy of herb and drug is the need for the management of many complex diseases, which cannot be managed with the current treatment...
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Photoimmunotherapy for Cancer Treatment
Cancer, as one of the diseases with high mortality rates in the world, has received enormous attention from people. Conventional therapeutic...
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Databases for Rational Design and Discovery of Multitarget Drugs
Rational drug design and discovery, particularly rational multitarget drug (MTD) design and discovery, heavily relies on computational approaches...
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Basics of Polypharmacology
Polypharmacology is frequently referred to the design or use of pharmaceutical agents that act on multiple molecular targets or multiple signaling...
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Future Prospects on Synergistic Herb-Drug Interactions
In the recent decades, a substantial progress has been made in the field of drug-drug and adverse herb-drug interactions. Synergistic herb-drug...
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A human paradigm of LHX4 and NR5A1 developmental gene interaction in the pituitary gland and ovary?
The pituitary gland, as a nodal component of the endocrine system, is responsible for the regulation of growth, reproduction, metabolism, and...
