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Electronic Cigarette Va** with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Electronic cigarette (EC) va** is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC...
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Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
BackgroundIndividuals with Alzheimer’s disease (AD) often require many medications; however, these medications are dosed using regimens recommended...
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Microvascular Endothelial Glycocalyx Surface Layer Visualization and Quantification
As a primary interface between the blood and underlying vascular wall, the endothelial glycocalyx layer is common to all blood vessels and covers the...
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Roles of mitochondrial dynamics and mitophagy in diabetic myocardial microvascular injury
Myocardial microvessels are composed of a monolayer of endothelial cells, which play a crucial role in maintaining vascular barrier function, luminal...
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Computational Fractal-Based Analysis of Brain Tumor Microvascular Networks
Brain parenchyma microvasculature is set in disarray in the presence of tumors, and malignant brain tumors are among the most vascularized neoplasms...
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Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Endothelial cells (ECs), found in the innermost layer of blood vessels, are crucial for maintaining the structure and function of coronary...
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Determination of Solute Permeability of Microvascular Endothelial Cell Monolayers In Vitro
The microvascular endothelium has a critical role in regulating the delivery of oxygen, nutrients, and water to the surrounding tissues. Under...
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Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques
Reactive hyperemia is a well-established technique for the non-invasive evaluation of the peripheral microcirculatory function, measured as the...
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Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of...
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ENPP2 alleviates hypoxia/reoxygenation injury and ferroptosis by regulating oxidative stress and mitochondrial function in human cardiac microvascular endothelial cells
This study aimed to elucidate the molecular mechanisms of hypoxia/reoxygenation (H/R) injury in human cardiac microvascular endothelial cells...
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Investigating the Function of MicroRNAs in Human Retinal Microvascular Endothelial Cells of Diabetic Retinopathy
Diabetic retinopathy (DR) is the main complication of diabetes mellitus (DM). Recent studies have implicated microRNAs dysfunction in human retinal...
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Association between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study
BackgroundRetinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with...
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Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia
Hypercholesterolemia affects the neurovascular unit, including the cerebral blood vessel endothelium. Operation of this system, especially in the...
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Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro
Influenza H7N9 virus causes human infections with about 40% case fatality rate. The severe cases usually present with pneumonia; however, some...
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Strenuous exercise in warm environment is associated with improved microvascular function in sickle cell trait
PurposeSickle cell trait is characterized by the presence of both normal and abnormal haemoglobin in red blood cells. The rate of exertional collapse...
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A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity
Biomimetic tumor microenvironment models bridge the gap between in vitro and in vivo systems and serve as a useful way to address the modeling...
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Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro...
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Pathology and prevention of brain microvascular and neuronal dysfunction induced by a high-fructose diet in rats
A high-fructose diet causes metabolic abnormalities in rats, and the cluster of complications points to microvascular and neuronal disorders of the...
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Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some...
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Immunolocalization of zinc transporters and metallothioneins reveals links to microvascular morphology and functions
Zinc homeostasis is vital to immune and other organ system functions, yet over a quarter of the world’s population is zinc deficient. Abnormal zinc...
