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Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood....
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ADAMTS1 Is Differentially Expressed in Human Lymphocytes with Various Frequencies of Endogenous γH2AX Foci and Radiation-Induced Micronuclei
AbstractThe level of spontaneous and radiation-induced DNA damage varies depending on genetic and environmental factors in human somatic cells. This...
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CDK4/6 inhibitor-induced bone marrow micronuclei might be caused by cell cycle arrest during erythropoiesis
BackgroundA micronucleus test is generally used to evaluate the genotoxic potential of chemicals. Exaggerated erythropoiesis, as occurs following...
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Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells
Micronuclei are small nuclear cellular structures containing whole chromosomes or chromosomal fragments. While there is a lot of information...
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LINE-1 Methylation Index Correlates with Sister Chromatid Exchanges and Chromatid but Not Chromosome Aberrations in Personnel from a Nuclear Chemical Facility with Incorporated Plutonium-239
AbstractThe level of chromosomal abnormalities in the somatic cells of adult individuals is characterized by significant interindividual variability,...
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Application of image-recognition techniques to automated micronucleus detection in the in vitro micronucleus assay
BackgroundAn in vitro micronucleus assay is a standard genotoxicity test. Although the technique and interpretation of the results are simple, manual...
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Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway
BackgroundCurrent immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often...
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Morphofunctional Differences of Micronuclei in Cultures of Human p53-Positive and p53-Negative Tumor Cells
Micronuclei that are often present in tumor cells are not only the indicator of genetic instability, they also can induce DNA damage during cell...
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Co-exposure of monocrotophos and ethanol synergistically induced cytotoxicity in keratinocytes and alveolar epithelium cells
ObjectivesTo compare the effects of MCP and ethanol co-exposure on cytotoxicity in nourished and malnourished keratinocytes and lung alveolar...
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Evaluating Chromosome Instability and Genotoxicity Through Single Cell Quantitative Imaging Microscopy
Across eukaryotes, genome stability is essential for normal cell function, physiology, and species survival. Aberrant expression of key genes or...
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Micronucleus Assay in Lymphocytes for Human Biomonitoring and Clinical Studies
Micronuclei (MN) are originated when a whole or broken chromosome/chromatin lag at the anaphase of dividing cells and becomes separated from the main...
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Micronuclei Formation Analysis After Ionizing Radiation
Micronuclei are formed by broken chromosome fragments or chromosomes, which were not appropriately separated into the daughter cells’ nuclei after...
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Learning from NATO Biomarker Research for Humans
Early knowledge of the absorbed dose is of paramount importance in radiation emergencies in order to focus the available resources only on those...
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Cytotoxicity and immunological impact of Trypanosoma sp. infection on blood parameters of wild African catfish, Clarias gariepinus
Fish trypanosomiasis is a common blood parasitic disease transmitted by aquatic invertebrates, such as leeches. This study aims to shed light on the...
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Bovine Whole Blood Cells as a Biomarker Platform for Biological Toxicology: A Focus on Thiacloprid
In the present work, we deal with using bovine whole blood cells in cytotoxicity and genotoxicity studies of neonicotinoid insecticide thiacloprid...
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TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
PurposeTIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6...
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Detection of Nuclear Biomarkers for Chromosomal Instability
Chromosomal instability (CIN) is a hallmark of cancer, which is characterized by the gain or loss of chromosomes as well as the rearrangement of the...
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Micronucleus Assay in Lymphocytes for Human Biomonitoring and Clinical Studies
Micronuclei (MN) are originated when a whole or broken chromosome/chromatin lag at the anaphase of dividing cells and becomes separated from the main...
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The Length of Telomeres and the Baseline Level of Cytogenetic Damage in Leukocytes of Lung Cancer Patients
AbstractDespite the great efforts of basic and clinical research on lung cancer (LC), the prevention and treatment of this type of cancer show still...
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Effect of ADAMTS1 Differential Expression on the Radiation-Induced Response of HеLа Cell Line
AbstractThe effect of knockout and overexpression of the ADAMTS1 on the radiation-induced response in HeLa cell line was analyzed. The cell line...
