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Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway
Berberine (BBR), a natural isoquinoline alkaloid exhibiting insulin sensitizing activity, has been applicated in the treatment of diabetes. However,...
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RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA
BackgroundMEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting...
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Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
BackgroundIn idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective...
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Identifying Network Biomarkers for Alzheimer’s Disease Using Single-Cell RNA Sequencing Data
System-level network-based approaches are an emerging field in the biomedical domain since biological networks can be used to analyze complicated...
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Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways
Diabetes kidney disease (DKD) is one of the common chronic microvascular complications of diabetes, which has become the most important cause of...
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HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3
BackgroundHistone deacetylases (HDACs) have been shown to be involved in tumorigenesis, but their precise role and molecular mechanisms in gastric...
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Krebssignalwege
Die Proliferation, Differenzierung und das Überleben normaler Zellen werden durch miteinander verknüpfte Wege reguliert, die Signale von...
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Hel** Leukemia Cells to Die with Natural or Chemical Compounds Through H2O2 Signaling
Leukemia disorders have showed resistance to conventional treatment. Therefore, the idea of treating them with drugs that either directly or...
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Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation
Parkinson’s disease (PD) is a common neurodegenerative motor disorder characterized by a dramatic reduction in pars compacta of substantia nigra...
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MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer
PurposeIn this study, we assessed whether the overexpression of MAP3K1 promotes the proliferation, migration, and invasion of breast cancer cells,...
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Cancer Pathways
Proliferation, differentiation, and survival of normal cells are regulated by interlinked pathways that transmit and integrate signals from growth...
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Anoikis Mediated by Stress-Activated MAPK Signaling Pathways
The JUN NH2-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs) represent a group of signaling enzymes that are collectively...
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Structure Composition and Intracellular Transport of Clathrin-Mediated Intestinal Transmembrane Tight Junction Protein
Tight junctions (TJs) are located in the apical region of the junctions between epithelial cells and are widely found in organs such as the brain,...
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The endoplasmic reticulum unfolded protein response varies depending on the affected region of the tissue but independently from the source of stress
Accumulation of unfolded proteins and calcium dyshomeostasis induces endoplasmic reticulum (ER) stress, which can be resolved by the unfolded protein...
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Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis
BackgroundTumor necrosis factor receptor-associated factor 3 (TRAF3) has specific regulatory effects on a wide range of diseases, including tumors....
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Infantile hemangioma models: is the needle in a haystack?
Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with distinct disease stages and durations. Despite the fact that...
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Hel** Leukemia Cells to Die with Natural or Chemical Compounds Through H2O2 Signaling
Leukemia disorders have showed resistance to conventional treatment. Therefore, the idea of treating them with drugs that either directly or...
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MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells
BackgroundChemotherapy is one of the most common treatment options for breast cancer (BC) patients. However, about half of the BC patients are...
