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Hel** Leukemia Cells to Die with Natural or Chemical Compounds Through H2O2 Signaling

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Leukemia disorders have showed resistance to conventional treatment. Therefore, the idea of treating them with drugs that either directly or indirectly generates oxidative stress (OS) and hydrogen peroxide (H2O2) as effective therapeutic strategy for selectively pushing those cells over reactive oxygen species (ROS) threshold and induce apoptosis has ultimately gained scientific momentum. Our research group has focused on unrevealing the molecular mechanism of OS/H2O2 -induced apoptosis in leukemia cells by metabolic alterations (e.g., glucose starvation, fructose as only energetic source) and some selected natural or chemical agents including vitamin C, vitamin K3, vitamin E D-α-tocopheryl polyethylene glycol succinate, snake venom metalloproteinase nasulysin-1, and l-amino oxidase MipLAAO, avocado extracts, mitochondrial complex I inhibitor rotenone, metal chelator TPEN, antibiotic doxorubicin, and minocycline. Original published work by the authors and the PubMed database was consulted to compile this review. Therefore, this review aims to provide hematologists and physicians with an overview of results from in vitro models illustrating the complex interactions between metabolisms, natural and chemical molecules, OS, and apoptosis as therapeutic strategy against leukemia.

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Abbreviations

ABL1 :

Abelson murine leukemia viral oncogene homolog 1

ALL :

acute lymphoblastic leukemia

AML :

acute myelogenous leukemia

BCR :

breakpoint cluster region

BAX :

Bcl-2-associated X protein

BAD :

Bcl-2-associated death promoter

BID :

BH3-interacting domain death agonist

BOK :

Bcl-2-related ovarian killer

BIK :

Bcl-2-interacting killer

BAK :

Bcl-2 homologous antagonist killer

CLL :

chronic lymphoblastic leukemia

CML :

chronic myelogenous leukemia

DOX :

doxorubicin

GS :

glucose starvation

H 2 O 2 :

hydrogen peroxide

MipLAAO :

Microrus mipartitus l-amino oxidase

MC :

minocyclin

OS :

oxidative stress

PUMA :

p53 upregulated modulator of apoptosis

ROS :

reactive oxygen species

ROT :

rotenone

RCD :

regulated cell death

TPEN :

N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine

TPGS :

D-α-tocopheryl polyethylene glycol succinate

VC :

vitamin C

VK3 :

vitamin K3

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Acknowledgements

This work was supported by the University of Antioquia, UdeA, and “Fundación Alfonso Moreno Jaramillo” grants #2017-16748 and #2018-20454 to CV-P and MJ-Del-R. The funders had no role, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Medellin, Colombia

    Carlos Velez-Pardo & Marlene Jimenez-Del-Rio

Authors
  1. Carlos Velez-Pardo
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  2. Marlene Jimenez-Del-Rio
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Corresponding author

Correspondence to Marlene Jimenez-Del-Rio .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Velez-Pardo, C., Jimenez-Del-Rio, M. (2022). Hel** Leukemia Cells to Die with Natural or Chemical Compounds Through H2O2 Signaling. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_45

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