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An Advanced Intrahepatic Cholangiocarcinoma Patient Benefits from Personalized Immunotherapy
Advanced intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy characterized by limited response to standard therapeutic...
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Precision oncology for intrahepatic cholangiocarcinoma in clinical practice
BackgroundAdvanced cholangiocarcinoma has a poor prognosis. Molecular targeted approaches have been proposed for patients after progression under...
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Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy
BackgroundCirrhosis is a risk factor for intrahepatic cholangiocarcinoma (iCC). However, its exact prevalence is uncertain and its impact on the...
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Identification of FOXP1 as a favorable prognostic biomarker and tumor suppressor in intrahepatic cholangiocarcinoma
BackgroundForkhead-box protein P1 (FOXP1) has been proposed to have both oncogenic and tumor-suppressive properties, depending on tumor...
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Exploration of a screening model for intrahepatic cholangiocarcinoma patients prone to cuproptosis and mechanisms of the susceptibility of CD274-knockdown intrahepatic cholangiocarcinoma cells to cuproptosis
Intrahepatic cholangiocarcinoma (ICC) is a form of liver cancer with poor long-term survival rates that requires novel therapeutic methods. Our...
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Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients
BackgroundCollagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression pattern and the...
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Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma
BackgroundAnnexin A10 expression influences the prognosis of several gastrointestinal cancers. We explored the association of annexin A10 expression...
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Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway
BackgroundIntrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent...
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Differential enrichment of H3K9me3 in intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (ICC) is a malignant tumor, which poses a serious threat to human health. Histone 3 lysine 9 trimethylation...
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Using immunovascular characteristics to predict very early recurrence and prognosis of resectable intrahepatic cholangiocarcinoma
ObjectiveTo predict the very early recurrence (VER) of patients with intrahepatic cholangiocarcinoma (ICC) based on TLSs and MVI status, and further...
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Serum thrombospondin-1 serves as a novel biomarker and agonist of gemcitabine-based chemotherapy in intrahepatic cholangiocarcinoma
BackgroundAt present, the first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC) is gemcitabine combined with cisplatin, but a...
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Oncogene-Driven Induction of Orthotopic Cholangiocarcinoma in Mice
Cholangiocarcinoma (CCA) is a malignancy affecting the epithelial cells that line the bile ducts. This cancer shows a poor prognosis and current...
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Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
BackgroundThe Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the...
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Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population
BackgroundMost patients with intrahepatic cholangiocarcinoma (ICC) have developed distant metastasis at the time of diagnosis, while there is rear...
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Establishment and characterization of a new intrahepatic cholangiocarcinoma cell line derived from a Chinese patient
Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection...
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Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and...
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HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent...
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Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
BackgroundDriver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with...
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Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary
BackgroundMany patients referred with a provisional diagnosis of cancer of unknown primary (pCUP) present with presumed metastatic disease to the...
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Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation
BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of...
