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Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route
Because of their high specificity, high affinity, and targeting, antibody drugs have been widely used in the treatment of many diseases and have...
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Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel
PurposeSystemic absorption is the process of drug movement from the site of drug administration to systemic circulation for therapeutic efficacy....
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Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats
BackgroundPhysiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of...
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Intravitreal Injection of AAV for the Transduction of Mouse Retinal Ganglion Cells
The injection of therapies into the eye is common practice, both clinically and pre-clinically. The most straightforward delivery route is via an...
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Activation dynamics of antigen presenting cells in vivo against Mycobacterium bovis BCG in different immunized route
BackgroundControl of Tuberculosis (TB) infection is mainly the result of productive teamwork between T-cell populations and antigen presenting cells...
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Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading...
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Δ9-Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
The physiological impact of cannabinoid receptor agonists is of great public health interest due to their increased use in recreational and...
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Nanomedicines via the pulmonary route: a promising strategy to reach the target?
Over the past decades, research on nanomedicines as innovative tools in combating complex pathologies has increased tenfold, spanning fields from...
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Nano vs Resistant Tuberculosis: Taking the Lung Route
Tuberculosis (TB) is among the top 10 infectious diseases worldwide. It is categorized among the leading killer diseases that are the reason for the...
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Nanocarrier-Mediated Drug Delivery via Inhalational Route for Lung Cancer Therapy: A Systematic and Updated Review
Lung cancer is one of the most severe lethal malignancies, with approximately 1.6 million deaths every year. Lung cancer can be broadly categorised...
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Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats
This study was designed to investigate the analgesic effect of perineural injection of BoNT/A on neuropathic pain induced by sciatic nerve chronic...
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Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring
Homosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis - and trans -isomers. Systemic absorption after...
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A DNA vaccine targeting VEE virus delivered by needle-free jet-injection protects macaques against aerosol challenge
We have previously shown that DNA vaccines expressing codon optimized alphavirus envelope glycoprotein genes protect both mice and nonhuman primates...
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Delivery of Experimental mRNA Vaccine Encoding the RBD of SARS-CoV-2 by Jet Injection
We studied a needle-free jet injection delivery of an experimental mRNA vaccine encoding the receptor-binding domain of the SARS-CoV-2 S protein...
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A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging
A method of drug delivery that could provide control over medicine reaching the bloodstream for systemic circulation would be of immense importance....
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SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters
PurposeTo construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue...
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Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size
PurposeLipid nanoparticles (LNPs) are widely utilized as means to deliver mRNA molecules. However, metric connections between biodistribution and...
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Develo** an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis
BackgroundThis study aims to develop an AI-based prediction model for injection drugs that cause anaphylactic shock using Japanese Real-World Data...
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A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice
Adeno-associated viruses (AAV) are commonly used in the scientific field due to their diverse application range. However, AAV shedding, the release...
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