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AIOLOS-Associated Inborn Errors of Immunity
AIOLOS, encoded by the IKZF3 gene, belongs to the Ikaros zinc finger transcription factor family and plays a pivotal role in regulating lymphocyte...
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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require strict control of effector...
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IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development
Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in innate lymphopoiesis is unknown. Using conditional...
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Aiolos regulates eosinophil migration into tissues
Expression of Ikaros family transcription factor IKZF3 (Aiolos) increases during murine eosinophil lineage commitment and maturation. Herein, we...
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Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome
BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical,...
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A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS
In the present study, we report a human-inherited, impaired, adaptive immunity disorder, which predominantly manifested as a B cell differentiation...
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Inborn errors of immunity—recent advances in research on the pathogenesis
Primary immunodeficiency (PID) is a genetic disorder with a defect of one of the important components of our immune system. Classical PID has been...
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Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance
Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the...
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Immunogenetics of Lupus Erythematosus
Lupus erythematosus (LE) is a heterogeneous disease with a wide range of manifestations ranging from localized lesions in cutaneous lupusCutaneous...
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IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study
BackgroundAssociations between IKZF1 gene variants and Acute Lymphoblastic Leukemia (ALL) was recently reported. We examined whether the common IKZF1 ...
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Advances in targeting ‘undruggable’ transcription factors with small molecules
Transcription factors (TFs) represent key biological players in diseases including cancer, autoimmunity, diabetes and cardiovascular disease....
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An overview of PROTACs: a promising drug discovery paradigm
Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm in recent years. PROTACs are heterobifunctional...
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Immune Dysregulation Leading to Autoimmunity
The immune system is a delicate equilibrium of checks and balances. Defects in different aspects of the immune system can disrupt this balance and...
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PROTAC targeted protein degraders: the past is prologue
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically...
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EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses
BackgroundEOS plays an important role in maintaining the suppressive function of regulatory T cells (Tregs), and induces a regulated transformation...
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How transcription factors drive choice of the T cell fate
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells....
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Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues
Innate lymphoid cells (ILCs) are tissue-resident lymphocytes categorized on the basis of their core regulatory programs and the expression of...
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The telomere complex and the origin of the cancer stem cell
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple...
