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Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in...
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Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease
Chronic kidney diseaQueryse (CKD) is associated with oxidative stress which can interrupt the nitric oxide (NO)/soluble guanylyl cyclase (sGC)...
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Cyclic GMP Signaling
Guanosine 3′5′ cyclic monophosphate (cGMP) is synthesized by soluble guanylyl cyclase (sGC) when vascular smooth muscle is stimulated with nitric...
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Nitric Oxide and Cardiovascular Health
Nitric oxide (NO) is a diffusible free radical and universal messenger that is produced from L-arginine by three different isoforms of nitric oxide...
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New insights on mode of action of vasorelaxant activity of simvastatin
Simvastatin is a semisynthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is used extensively to treat...
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Paracrine and endocrine pathways of natriuretic peptides assessed by ligand-receptor map** in the Japanese eel brain
The natriuretic peptide (NP) family consists of cardiac NPs (ANP, BNP, and VNP) and brain NPs (CNPs) in teleosts. In addition to CNP1-4, a paralogue...
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Plasticity of the Cerebellum
Since 1990s, long-term depression of (LTD) at parallel fiber–Purkinje cell synapses has been regarded as a cellular phenomenon for motor learning....
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Nitric Oxide as a Diagnostic and Therapeutic Tool in Respiratory Diseases
Nitric oxide (NO) is a gasotransmitter that plays a vital role in diverse biological processes. NO is a fundamental component in regulating...
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Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms
The present study aimed to evaluate the possible peripheral H 2 O 2 -induced antinociception and determine the involvement of opioidergic,...
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Alteration of Piezo1 signaling in type 2 diabetic mice: focus on endothelium and BKCa channel
Piezo1 mechanosensitive ion channel plays a important role in vascular physiology and disease. This study aimed to elucidate the altered signaling...
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The interaction between hippocampal cholinergic and nitrergic neurotransmission coordinates NMDA-dependent behavior and autonomic changes induced by contextual fear retrieval
RationaleRe-exposing an animal to an environment previously paired with an aversive stimulus evokes large alterations in behavioral and...
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The Role of Hydrogen Sulfide in the Dilatation of Mesenteric Lymphatic Vessels in Bulls
We studied the effects and mechanisms of action of NaHS, an H 2 S donor, on bovine isolated mesenteric efferent lymphatic vessels pre-contracted with...
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Oxidative and Nitrous Stress Underlies Vascular Malfunction Induced by Ionizing Radiation and Diabetes
Oxidative stress results from the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in quantities exceeding the...
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Renal and cardiac effects of the PDE9 inhibitor BAY 73–6691 in 5/6 nephrectomized rats
It has been suggested that the novel selective phosphodiesterase 9 (PDE9) inhibitor may improve cardiac and renal function by blocking 3′,5′-cyclic...
