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Plasticity of the Cerebellum

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Essentials of Cerebellum and Cerebellar Disorders

Abstract

Since 1990s, long-term depression of (LTD) at parallel fiber–Purkinje cell synapses has been regarded as a cellular phenomenon for motor learning. However, parallel fiber LTD by itself cannot account for motor learning. Here, we review a rich variety of use-dependent plasticity in the cerebellar cortex and nuclei, including long-term potentiation (LTP) and LTD at excitatory and inhibitory synapses, and persistent modulation of intrinsic excitability. Prevailing studies demonstrated that intrinsic and extrinsic factors, including neuronal excitation, specific molecular mechanisms, theta oscillation, and external neuromodulators, are essential to different forms of plasticity in the cerebellum.

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Authors and Affiliations

  1. Department of Physiology, Zhejiang University School of Medicine, Hangzhou, P. R. China

    **n-Tai Wang & Ying Shen

Authors
  1. **n-Tai Wang
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  2. Ying Shen
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Corresponding author

Correspondence to Ying Shen .

Editor information

Editors and Affiliations

  1. Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

  2. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  3. Service de Neurologie, CHU-Charleroi, Charleroi, Belgium

    Mario Manto

  4. Clinical Translational Research, Santa Lucia Foundation, Rome, Italy

    Marco Molinari

  5. Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  6. Department of Physiology, Zhejiang University School of Medicine, Hangzho, China

    Ying Shen

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Wang, XT., Shen, Y. (2023). Plasticity of the Cerebellum. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_43

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