Search
Search Results
-
Restoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma
BackgroundKidney renal clear cell carcinoma (KIRC) is the major histological subtype of kidney tumor which covers approximately 80% of the cases....
-
Berberine ameliorates glucocorticoid-induced hyperglycemia: an in vitro and in vivo study
Berberine (BBR), a bioactive compound isolated from Coptidis Rhizoma, possesses diverse pharmacological activities including anti-bacterial,...
-
Integration of transcriptomics and metabolomics reveals pathways involved in MDSC supernatant attenuation of TGF-β1-induced myofibroblastic differentiation of mesenchymal stem cells
Overexposure to transforming growth factor b1 (TGF-β1) induces myofibroblastic differentiation of mesenchymal stem cells (MSCs), which could be...
-
Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid
BackgroundThe cancer microbiota was considered the main risk factor for cancer progression. We had proved that Fusobacterium periodonticum (F.p) was...
-
PGK1 Is Involved in the HIF-1 Signaling Pathway as a Hub Gene for Ferroptosis After Traumatic Brain Injury
The pathogenesis of ferroptosis in traumatic brain injury (TBI) is unclear; therefore, we aimed to identify key molecules associated with ferroptosis...
-
Enolase
Glycolysis is an ancient metabolic, oxygen-dependent, mostly cytosolic pathway that brings about conversion of glucose to pyruvate with the release...
-
Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer
BackgroundBreast cancer (BC) exhibits remarkable heterogeneity. However, the transcriptomic heterogeneity of BC at the single-cell level has not been...
-
A quantitative proteomic approach revealed variations of salivary proteome during high altitude de-acclimatization
De-acclimatization occurs when an individual returns to sea level after long term exposure to high altitude. Reports on high altitude...
-
Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review
Silibinin, or silybin, is a polyphenolic flavonoid and the main active component of silymarin, isolated from the seeds of the milk thistle plant ( Sily...
-
Regional vulnerability of brain white matter in vanishing white matter
Vanishing white matter (VWM) is a leukodystrophy that primarily manifests in young children. In this disease, the brain white matter is...
-
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis
Endoplasmic reticulum (ER) stress has been implicated in the mechanisms underlying the fibrotic process in dilated cardiomyopathy (DCM) and results...
-
Targeted Metabolomic Analysis of the Eye Tissue of Triple Transgenic Alzheimer’s Disease Mice at an Early Pathological Stage
Alzheimer’s disease (AD) is a severe neurodegenerative disease in older people. Despite some consensus on pathogenesis of AD established by previous...
-
Oxidase enzyme genes are differentially expressed during Acanthamoeba castellanii encystment
Acanthamoeba castellanii , a ubiquitous protozoan, is responsible for significant diseases such as Acanthamoeba keratitis and granulomatous amoebic...
-
Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia
Acute myeloid leukemia (AML) has the lowest survival rate among the leukemias. Targeting intracellular metabolism and energy production in leukemic...
-
Global Quantitative Proteomics Analysis Reveals the Downstream Signaling Networks of Msx1 and Msx2 in Myoblast Differentiation
The msh homeobox 1 (Msx1) and msh homeobox 2 (Msx2) coordinate in myoblast differentiation and also contribute to muscle defects if altered during...
-
Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells
BackgroundDeregulated glucose metabolism is a critical component of cancer growth and survival, clinically evident via FDG-PET imaging of enhanced...
-
Hepatic Glucose Metabolism and Its Disorders in Fish
Carbohydrate, which is the most abundant nutrient in plant-sourced feedstuffs, is an economically indispensable component in commercial compound...
-
Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach
ObjectiveHepatic carcinoma is one of the most common types of malignant tumors in the digestive system, and its biological characteristics determine...
-
Enolase
Glycolysis is an ancient metabolic, oxygen-dependent, mostly cytosolic pathway that brings about conversion of glucose to pyruvate with the release...
-
A Charge Variant of Bevacizumab Offers Enhanced FcRn-Dependent Pharmacokinetic Half-Life and Efficacy
BackgroundLysine variants of monoclonal antibodies (mAbs) result from incomplete clip** of the C-terminal lysine residues of the heavy chain....
