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Hereditary Cancer Syndromes and Cancer Metastasis
Hereditary cancer syndromes, also known as familial or inherited cancer syndromes, are inherited genetic disorders that are associated with increased...
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Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy
Brain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the...
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The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study
Breast cancer in young patients is known to exhibit more aggressive biological behavior and is associated with a less favorable prognosis than the...
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Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature
BackgroundIntracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of...
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Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes
Several medical conditions that interest both the brain and the spinal cordSpinal cord have been described throughout the history of medicine....
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Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles
Cancer is a systemic disease that induces functional dysregulation in multiple tissues and organs. The great majority of cancer-related deaths are...
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Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters...
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Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter
Metastasis to distant organs and particularly the brain still represents the most serious obstacle in melanoma therapies. Melanoma cells acquire a...
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A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2
Germline double heterozygosity (GDH) is rarely reported in cases of inherited cancer syndromes, and GDH of a mismatch repair gene and BRCA has never...
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Photoimmunotherapy for Cancer Treatment
Cancer, as one of the diseases with high mortality rates in the world, has received enormous attention from people. Conventional therapeutic...
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Therapeutic targeting of the functionally elusive TAM receptor family
The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune homeostasis. Aberrant TAM receptor signalling has been linked to a range...
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Imaging biomarkers for evaluating tumor response: RECIST and beyond
Response Evaluation Criteria in Solid Tumors (RECIST) is the gold standard for assessment of treatment response in solid tumors. Morphologic change...
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Atypical Patterns of Metastases: How Do Sarcomas Metastasize?
Soft tissue sarcoma is a rare and heterogeneous group of cancers and comprises around 1% of all malignancies. This group of tumors consists of more...
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Clinical and genomic correlates of imatinib response in melanomas with KIT alterations
BackgroundImatinib is an active agent for some patients with melanoma harbouring c-KIT alterations. However, the genetic and clinical features that...
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Perspectives on the role of brain cellular players in cancer-associated brain metastasis: translational approach to understand molecular mechanism of tumor progression
Brain metastasis is one of the leading causes of death among cancer patients. Cancer cells migrate to various sites and harbor different niche in the...
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Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell...
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Metastasis in the wild: investigating metastasis in non-laboratory animals
Humans are not the only species to spontaneously develop metastatic cancer as cases of metastasis have been reported in a wide range of animals,...
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KDM4 Demethylases: Structure, Function, and Inhibitors
KDM4 histone demethylases mainly catalyze the removal of methyl marks from H3K9 and H3K36 to epigenetically regulate chromatin structure and gene...
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Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalised Cancer Treatments
Cancer was until recently considered a homogenous disease with clearly defined boundaries based on the organ involved and the TNM stage of a tumour....
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Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review
BackgroundWhile denosumab has been shown to prevent skeletal-related events in patients with bone metastasis, there is a concern that it may cause...
