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Atypical Patterns of Metastases: How Do Sarcomas Metastasize?

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Cancer Metastasis Through the Lymphovascular System

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Abstract

Soft tissue sarcoma is a rare and heterogeneous group of cancers and comprises around 1% of all malignancies. This group of tumors consists of more than 60 different subtypes, each varying in biology and clinical behavior. In general, between 25% and 50% of the patients develop local or distant recurrences. However, the propensity of sarcoma to metastasize depends on many different factors, such as histological subtype, anatomical site, size, and grade. Most of the STS subtypes have a tendency to spread hematogenously with a predilection for pulmonary seeding, while lymph node metastases are rarely seen. However, there are several subtypes with deviating metastatic patterns, and in this chapter, the different atypical metastatic patterns are being described.

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Authors and Affiliations

  1. Department of Surgical Oncology, Sarcoma and Melanoma Unit, The Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, The Netherlands

    Pia van der Laan & Winan J. van Houdt

  2. Department of Sarcoma Surgery, Queen Elizabeth Hospital, Birmingham, UK

    Fabio Tirotta & Samuel Ford

  3. Division of Molecular Pathology, The Institute of Cancer Research, London, UK

    Valeriya Pankova & Paul Huang

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  1. Pia van der Laan
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  2. Fabio Tirotta
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  3. Valeriya Pankova
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  4. Samuel Ford
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  5. Paul Huang
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  6. Winan J. van Houdt
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Correspondence to Winan J. van Houdt .

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Editors and Affiliations

  1. Department of Surgery and Melanoma Center, California Pacific Medical Center and Research Institute, San Francisco, CA, USA

    Stanley P. Leong

  2. Henry Ford Cancer Institute, Detroit, MI, USA

    S. David Nathanson

  3. Moffitt Cancer Center, Tampa, FL, USA

    Jonathan S. Zager

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van der Laan, P., Tirotta, F., Pankova, V., Ford, S., Huang, P., van Houdt, W.J. (2022). Atypical Patterns of Metastases: How Do Sarcomas Metastasize?. In: Leong, S.P., Nathanson, S.D., Zager, J.S. (eds) Cancer Metastasis Through the Lymphovascular System. Springer, Cham. https://doi.org/10.1007/978-3-030-93084-4_60

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