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A ThT Derivative as Zn2+ Sensor Based on DNA G-quadruplex
In this report, we developed a sensing strategy based on ThT-E (a ThT derivative) and DNA G-quadruplex for the label-free detection of Zn 2+ . In the...
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Identification of G-quadruplex DNA sequences in SARS-CoV2
G-quadruplex structure or Putative Quadruplex Sequences (PQSs) are abundant in human, microbial, DNA, or RNA viral genomes. These sequences in RNA...
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A novel aptamer-G-quadruplex/hemin self-assembling color system: rapid visual diagnosis of invasive fungal infections
BackgroundThe clinical symptoms of invasive fungal infections (IFI) are nonspecific, and early clinical diagnosis is challenging, resulting in high...
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G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome: methodologies and crosstalk
G-quadruplex (G4) is a non-canonical DNA second structure formed on specific G-rich sequences which are enriched in transcriptional regulatory...
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Ligands stimulating antitumour immunity as the next G-quadruplex challenge
G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not...
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Oxidative Stress Modulation by G-quadruplex Binder-Naphthalene Diimide Derivatives and Its Therapeutic Potential
G-quadruplexes are atypical four stranded structures of DNA formed as a result of guanine residues stacking in a G-tetrad plane. These G-quadruplex...
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Oxidative Stress Modulation by G-quadruplex Binder-naphthalene Diimide Derivatives and its Therapeutic Potential
G-quadruplexes are atypical four stranded structures of DNA formed as a result of guanine residues stacking in a G-tetrad plane. These G-quadruplex...
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A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome
BackgroundG-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now...
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TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
BackgroundMultiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability, and telomere dysfunction is an important cause...
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Label-free Aptasensor for the Ultrasensitive Detection of Insulin Via a Synergistic Fluorescent Turn-on Strategy Based on G-quadruplex and AIEgens
Insulin, the only hormone regulating blood glucose level, is strongly associated with diabetes and its complications. Specific recognition and...
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TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent mutational or functional inactivation in human cancers. Recurrent...
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A Fluorescence Biosensor Based on Carbon Quantum Dots Prepared from Pomegranate Peel and T-Hg2+-T Mismatch for Hg2+ Detection
Mercury ions (Hg 2+ ) can cause damage to human health, and thus, the study of the detection of Hg 2+ is extraordinarily important in daily life. This...
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General Gel-sol Method to Synthesize Various Highly Fluorescent Nanoclusters and Assay of Nuclease with the Near Infrared-emitting Gold Nanoclusters
A general egg white gel-sol strategy for fabrication of highly fluorescent Au, Ag, Cu, and Pt nanoclusters (NCs) and the first example of using Au...
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A Ratiometric Fluorescence Biosensor for Detection of Alkaline Phosphatase Via an Advanced Chemometric Model
In this paper, a ratiometric fluorescence biosensor was introduced for alkaline phosphatase (ALP) detection based on 2-aminopurine (2-Amp) and...
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Landscape of G-quadruplex DNA structural regions in breast cancer
Response and resistance to anticancer therapies vary due to intertumor and intratumor heterogeneity
1 . Here, we map differentially enriched...
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
BackgroundAcute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth...
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G-Quadruplex Nucleic Acids Methods and Protocols
This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic...
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NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds
G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These...
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Mass Spectroscopic Study of G-Quadruplex
Mass spectrometry (MS) is an analytical tool complimentary for being sensitive, accurate, and versatile in its application, such as the...
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Single-Molecule Investigations of G-Quadruplex
The genome-wide occurrence of G-quadruplexes and their demonstrated biological activities call for detailed understanding on the stability and...