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Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
RationaleStress during childhood or adolescence increases vulnerability to psychiatric disorders in adults. In adult rodents, the delayed effects of...
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Associations between the use of insecticide-treated nets in early childhood and educational outcomes, marriage and child-bearing in early adulthood: evidence from a 22-year prospective cohort study in Tanzania
BackgroundThe effectiveness of insecticide-treated nets (ITNs) in preventing malaria in young children is well established. However, the long-term...
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Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood
Stress exposure during early stages of life elevates the risk of develo** psychopathologies and psychiatric illness in later life. The brain and...
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DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
BackgroundPuberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early...
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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories...
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Altered Topographic Distribution and Enhanced Neuronal Expression of Adenosine-Metabolizing Enzymes in Rat Hippocampus and Cortex from Early to late Adulthood
The present study demonstrates altered topographic distribution and enhanced neuronal expression of major adenosine-metabolizing enzymes, i.e....
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Weigh change across adulthood is related to the presence of NAFLD: results from NHANES III
BackgroundObesity is a widely recognized driving factor of Non-alcoholic fatty liver disease (NAFLD), it remains unclear whether historical weight...
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Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
RationaleIntensely stressful experiences can lead to long-lasting changes in appetitive and aversive behaviors. In humans, post-traumatic stress...
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Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density
BackgroundAdolescence and early adulthood has been identified as a critical time window for establishing breast cancer risk. Mammographic density is...
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Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
BackgroundGrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with atherosclerotic cardiovascular...
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Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood
BackgroundEarly-life adversities during development (e.g., child abuse and neglect) are linked to multiple behavioral and cognitive dysfunctions,...
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Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
BackgroundBody fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and...
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Fetal Alcohol Spectrum Disorder: Challenges in Adulthood
Although frequently viewed as a childhood disorder, FASD is a lifelong condition with implications for function and well-being across the lifespan....
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Insight into the longitudinal relationship between chronic subclinical inflammation and obesity from adolescence to early adulthood: a dual trajectory analysis
Objectives and designThis study aimed to understand the longitudinal relationship between C-reactive protein (CRP) and body mass index (BMI) from...
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Aberrant Hippocampal Development in Early-onset Mental Disorders and Promising Interventions: Evidence from a Translational Study
Early-onset mental disorders are associated with disrupted neurodevelopmental processes during adolescence. The methylazoxymethanol acetate (MAM)...
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Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features
Superficial white matter (SWM) represents a significantly understudied part of the human brain, despite comprising a large portion of brain volume...
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The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates
Nicotine and tobacco product (NTP) use remains prevalent in adolescence/young adulthood. The effects of NTPs on markers of brain health during this...
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Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB
BackgroundMucopolysaccharidosis (MPS) IIIB, also known as Sanfilippo Syndrome B, is a devastating childhood disease. Unfortunately, there are...
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Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood
Despite growing concern about adverse effects of bisphenol AF (BPAF) due to its endocrine disrupting properties, there is a lack of toxicity data...
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BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018
BackgroundStudies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight...
