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Weight-Drop Method for Inducing Closed Head Diffuse Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the foremost causes of disability and death globally. Prerequisites for successful therapy of disabilities...
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Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits
Cerebellar dysfunction is commonly observed following traumatic brain injury (TBI). While direct impact to the cerebellum by TBI is rare, cerebellar...
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The Relationship Between Cortical Morphological and Functional Topological Properties and Clinical Manifestations in Patients with Posttraumatic Diffuse Axonal Injury: An Individual Brain Network Study
To evaluate the altered network topological properties and their clinical relevance in patients with posttraumatic diffuse axonal injury (DAI)....
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Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury
RationaleInfants born prematurely risk develo** diffuse white matter injury (WMI), which is associated with impaired cognitive functioning and an...
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Hyperglycemia Aggravates Blood–Brain Barrier Disruption Following Diffuse Axonal Injury by Increasing the Levels of Inflammatory Mediators through the PPARγ/Caveolin-1/TLR4 Pathway
Hyperglycemia aggravates brain damage after diffuse axonal injury (DAI), but the underlying mechanisms are not fully defined. In this study, we aimed...
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Traumatic Brain Injury
The most common traumatic brain injury type is mild form or concussion. This is especially a problem if these impacts happen frequently as in contact...
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Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence
Acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI) are heterogeneous conditions. The spatiotemporal evolution of...
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Brain injury drives optic glioma formation through neuron-glia signaling
Tissue injury and tumorigenesis share many cellular and molecular features, including immune cell (T cells, monocytes) infiltration and inflammatory...
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Altered DTI scalars in the hippocampus are associated with morphological and structural changes after traumatic brain injury
Blunt and diffuse injury is a highly prevalent form of traumatic brain injury (TBI) which can result in microstructural alterations in the brain. The...
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Traumatic brain injury heterogeneity affects cell death and autophagy
Traumatic brain injury (TBI) mechanism and severity are heterogenous clinically, resulting in a multitude of physical, cognitive, and behavioral...
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Ballooned neurons in semi-recent severe traumatic brain injury
Traumatic brain injury (TBI) is now recognized as an insult triggering a dynamic process of degeneration and regeneration potentially evolving for...
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Rat Model of Isoproterenol-Induced Myocardial Injury
Isoproterenol (ISO) administration produces significant biochemical and histological changes including oxidative stress, reactive oxygen species...
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Brain Tumor Networks in Diffuse Glioma
Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and molecular mechanisms driving the invasive growth patterns and...
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Nerve Injury and Biomarkers
The nervous system has enormous scale to its production. From the large-scale ganglia to the microscopic neuron, there is tremendous communication...
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Cyclosporine as Therapy for Traumatic Brain Injury
Drug development in traumatic brain injury (TBI) has been impeded by the complexity and heterogeneity of the disease pathology, as well as limited...
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Drug Delivery Strategies in Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the most prevalent reasons for persistent impairment as well as death as observed in both young and old...
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Radiotracers, Positron Emission Tomography Imaging and Traumatic Brain Injury
Over the last few decades, the expanded application of nuclear medicine has produced extensive knowledge of the pathophysiological processes...
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Serum cystatin C is correlated with mortality of traumatic brain injury patients partially mediated by acute kidney injury
BackgroundEvaluating risk of poor outcome for Traumatic Brain Injury (TBI) in early stage is necessary to make treatment strategies and decide the...
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Biomarkers of Cardiopulmonary Injury and Impact of Bromine Toxicity
Bromine is a highly oxidizing agent used in many industries. Therefore, it needs to be stockpiled and transported in significant quantities, making...
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Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury
Traumatic brain injury (TBI) is a leading cause of mortality, sensorimotor morbidity, and neurocognitive disability. Neuroinflammation is one of the...
