Search
Search Results
-
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
Thymic egress is a crucial process for thymocyte maturation, strictly regulated by sphingosine-1-phosphate lyase (S1PL). Recently, cystathionine...
-
USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase
BackgroundRadioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1)...
-
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
We aimed to investigate the mechanism underlying the roles of miRNA-377, Cystathionine-β-synthase (CBS), and hydrogen sulfide (H 2 S) in the...
-
Sepsis-Induced Inhibition of Contractile Function of Lymphatic Nodes
Inflammation accompanies most pathological processes, while the lymphatic system takes part in both the development and resolution of inflammation....
-
SAM, a cystathionine beta-synthase activator, promotes hydrogen sulfide to promote neural repair resulting from massive cerebral infarction induced by middle cerebral artery occlusion
Neurologic deterioration after massive cerebral infarct should be identified at an early stage for medical and surgical treatments. We investigated...
-
Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury
Ischemia/reperfusion (I/R) injury is a tissue damage during reperfusion after an ischemic condition. I/R injury is induced by pathological cases...
-
Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
BackgroundHydrogen sulfide (H 2 S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer...
-
H2S Regulates the Phenotypic Transformation of Astrocytes Following Cerebral Ischemia/Reperfusion via Inhibiting the RhoA/ROCK Pathway
The role of hydrogen sulfide (H 2 S) on the phenotypic change of astrocytes following cerebral ischemia/reperfusion (I/R) in mice was investigated in...
-
Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury
Hydrogen sulfide (H 2 S) is a gasotransmitter endogenously synthesized by cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and...
-
Activity of Gas Transmitters in Vessels of the Anterior Abdominal Wall after Implantation of a Polypropylene Mesh
The distribution of NO and H 2 S in the arterial vessels of the anterior abdominal wall after implantation of a polypropylene mesh was studied by...
-
Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis
Cystathionine-γ-lyase (CSE), an enzyme associated with hydrogen sulfide (H 2 S) production, is an important endogenous regulator of inflammation....
-
Hydrogen Sulfide and Pathophysiology of the CNS
The literature data and results of our research team concerning the physiological and pathological effects of hydrogen sulfide, a gas transmitter...
-
Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effects of Phosphodiesterase 5 Inhibitors
Phosphodiesterase 5 (PDE5) is an enzyme that catalyzes the degradation of cGMP to its inactive form, 5′-GMP. The inhibition of PDE5 leads to the...
-
Obesity-Induced Non-alcoholic Fatty Liver Disease (NAFLD): Role of Hyperhomocysteinemia
Non-alcoholic fatty liverNon-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease globally. NAFLD...
-
Mitochondrial Function in Health and Disease: Responses to Helicobacter pylori Metabolism and Impact in Gastric Cancer Development
Mitochondria are major cellular organelles that play an essential role in metabolism, stress response, immunity, and cell fate. Mitochondria are...
-
Homocysteine and Folic Acid Metabolism
Homocysteine (Hcy) and folate metabolism plays a crucial role in maintaining the overall human health. Hcy is a non-proteinogenic amino acid...
-
Cerebellar Biochemistry/Pharmacology
Cerebellar Purkinje cells (PCs) are localized in the cerebellar cortex and are characterized by highly developed dendrites, which receive different...
-
Homocysteine and Bone Health
Homocysteine is a sulfur-containing intermediary amino acid synthesized during methionine metabolism. Homocysteine has a significant role in the...
-
FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
BackgroundForkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a...
-
Study of hydrogen sulfide biosynthesis in synovial tissue from diabetes-associated osteoarthritis and its influence on macrophage phenotype and abundance
Type 2 diabetes (DB) is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases...
