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Connexin-Containing Vesicles for Drug Delivery
Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...
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Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies
BackgroundGerm cell tumors are relatively common in young men. They derive from a non-invasive precursor, called germ cell neoplasia in situ, but the...
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Astroglial Connexin 43-Mediated Gap Junctions and Hemichannels: Potential Antidepressant Mechanisms and the Link to Neuroinflammation
Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high suicide rate and a higher disability rate than any other...
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Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling
Diabetes is an independent risk factor for atrial fibrillation (AF). This study aimed to elucidate the pathophysiology of diabetes-related AF from...
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Connexin mRNA distribution in adult mouse kidneys
Kidneys are thought to express eight different connexin isoforms (i.e., Cx 26, 30, 32, 37, 40, 43, 45, and 46), which form either hemichannels or gap...
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Connexin 43 regulates astrocyte dysfunction and cognitive deficits in early life stress-treated mice
Early life stress such as maternal separation (MS), is a major risk factor for develo** psychiatric disorders in adulthood. Connexin 43 (CX43), the...
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Calcineurin-dependent regulation of gap junction conductance and connexin phosphorylation in guinea pig left atrium
Atrial fibrillation (AF) occurs from disordered atrial action potential conduction and is associated with reduced gap junction electrical conductance...
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Mechanisms of ATP release in pain: role of pannexin and connexin channels
Pain is a physiological response to bodily damage and serves as a warning of potential threat. Pain can also transform from an acute response to...
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Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy
Major depressive disorder (MDD), a chronic and recurrent disease characterized by anhedonia, pessimism or even suicidal thought, remains a major...
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Connexin 43 Promotes Neurogenesis via Regulating Aquaporin-4 after Cerebral Ischemia
We aimed to test the effects of connexin43 (Cx43) on ischemic neurogenesis and examined whether it was dependent on aquaporin-4 (AQP4). We detected...
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The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice
Depression is a common mood disorder characterized by a range of clinical symptoms, including prolonged low mood and diminished interest. Although...
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Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
BackgroundPostoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has...
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Connexin 43 hyper-phosphorylation at serine 282 triggers apoptosis in rat cardiomyocytes via activation of mitochondrial apoptotic pathway
Cx43 is the major connexin in ventricular gap junctions, and plays a pivotal role in control of electrical and metabolic communication among adjacent...
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Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination
BackgroundBrain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis...
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Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43
Rictor is a key component of the mammalian target of rapamycin complex 2 (mTORC2) and is required for Akt phosphorylation (Ser473). Our previous...
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The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell–cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway
Connexin 43 (Cx43) is the most important protein in the gap junction channel between cardiomyocytes. Abnormalities of Cx43 change the conduction...
