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Dosimetric benefits of adaptive radiation therapy for patients with stage III non-small cell lung cancer
BackgroundDaily adaptive radiation therapy (ART) of patients with non-small cell lung cancer (NSCLC) lowers organs at risk exposure while maintaining...
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Adoptive T-Cell Therapy for the Treatment of Lung Cancer
Lung cancer is an imminent health threat and the predominant cause of cancer-related fatalities worldwide. Significant advancements in identifying...
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Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated...
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Prospects for online adaptive radiation therapy (ART) for head and neck cancer
BackgroundThe aim of the present study is to examine the impact of kV-CBCT-based online adaptive radiation therapy (ART) on dosimetric parameters in...
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Evolution of cell therapy for renal cell carcinoma
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with...
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ctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results
Circulating tumor DNA (ctDNA) has shown promise in capturing primary resistance to immunotherapy. BR.36 is a multi-center, randomized,...
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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific...
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Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologies
Chimeric antigen receptor (CAR) T-cell therapy has made remarkable progress in cancer immunotherapy, but several challenges with unclear mechanisms...
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Outsmarting trogocytosis to boost CAR NK/T cell therapy
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer. However, the efficacy...
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A multi-center survey on adaptive radiation therapy for head and neck cancer in Malaysia
The survey is to assess the current state of adaptive radiation therapy (ART) for head and neck (H&N) cases among radiotherapy centers in Malaysia...
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Cell Therapy and Regenerative Pain Medicine: Preclinical Studies
Mesenchymal stem cells (MSCs) and bone marrow stem cells (BMSCs) represent a novel therapy for chronic pain due to their immunomodulatory and...
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Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
Normal cells explore multiple states to survive stresses encountered during development and self-renewal as well as environmental stresses such as...
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3D spheroid culture to examine adaptive therapy response in invading tumor cells
3D in vitro culture models of cancer cells in extracellular matrix (ECM) have been developed to investigate drug targeting and resistance or,...
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Immune Gene Therapy of Cancer
Cancer is the second global cause of mortality. Conventional treatments, such as chemotherapy and radiotherapy, have not provided desirable...
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Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific stressors, occupies a central position in the...
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Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with anti-PDL1 therapy effectively inhibits triple-negative breast cancer growth and metastasis
BackgroundAdoptive cell transfer cancer immunotherapy holds promise for treating disseminated disease, yet generating sufficient numbers of...
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B cells in head and neck squamous cell carcinoma: current opinion and novel therapy
Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which...
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Recent Innovative Approaches to Intensify the Efficacy and Safety of CAR-T Cell Therapy in Cancers
In recent decades, the advent of chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment, especially hematological...
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Bispecific T cell engager therapy for refractory rheumatoid arthritis
Bispecific T cell engagers (BiTEs) kill B cells by engaging T cells. BiTEs are highly effective in acute lymphoblastic leukemia. Here we treated six...
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Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy
BackgroundCellular immune responses are phenotypically and functionally perturbed during HIV-1 infection, with the majority of function restored upon...
